Update on Keratinocyte Carcinomas

Squamous-cell and basal-cell carcinomas of the skin are increasing in frequency. Basal-cell carcinomas are responsive to inhibition of the hedgehog pathway; squamous-cell cancers may be responsive to immune checkpoint inhibitors.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2018-07, Vol.379 (4), p.363-374
Hauptverfasser:	Nehal, Kishwer S, Bichakjian, Christopher K
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged Aged, 80 and over Antineoplastic Agents - therapeutic use Basal cell carcinoma Cancer therapies Carcinoma, Basal Cell - etiology Carcinoma, Basal Cell - pathology Carcinoma, Basal Cell - prevention & control Carcinoma, Basal Cell - therapy Carcinoma, Squamous Cell - etiology Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - prevention & control Carcinoma, Squamous Cell - therapy Female Health risk assessment HIV Human immunodeficiency virus Humans Immune checkpoint inhibitors Incidence Life Expectancy Male Melanoma Metastasis Mortality Mutation Neoplasm Recurrence, Local Neoplasm Staging Neural networks Proteins Quality of Life Radiotherapy, Adjuvant Risk Factors Skin Skin cancer Skin Neoplasms - etiology Skin Neoplasms - pathology Skin Neoplasms - prevention & control Skin Neoplasms - therapy Sunburn & sun tanning Transplants & implants
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Beschreibung
Zusammenfassung:	Squamous-cell and basal-cell carcinomas of the skin are increasing in frequency. Basal-cell carcinomas are responsive to inhibition of the hedgehog pathway; squamous-cell cancers may be responsive to immune checkpoint inhibitors.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMra1708701