A Nano-Combinatorial Library Strategy for the Discovery of Nanotubes with Reduced Protein-Binding, Cytotoxicity, and Immune Response

We have discovered functionalized multiwalled carbon nanotubes with reduced protein-binding, cytotoxicity, and immune response and the associated structure–activity relationships using in silico surface molecular diversity design, combinatorial library synthesis, and multiple biological screenings....

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Veröffentlicht in:	Nano letters 2008-03, Vol.8 (3), p.859-865
Hauptverfasser:	Zhou, Hongyu, Mu, Qingxin, Gao, Ningning, Liu, Aifeng, Xing, Yuehan, Gao, Sulian, Zhang, Qiu, Qu, Guangbo, Chen, Yuyan, Liu, Gang, Zhang, Bin, Yan, Bing
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biotechnology Cell Line Cell Survival - drug effects Cross-disciplinary physics: materials science rheology Databases, Factual Exact sciences and technology Fundamental and applied biological sciences. Psychology Humans Mass Spectrometry Materials science Methods. Procedures. Technologies Microscopy, Electron, Transmission Molecular Structure Nanocrystalline materials Nanoscale materials and structures: fabrication and characterization Nanotubes Nanotubes - chemistry Nanotubes - toxicity Nanotubes - ultrastructure Others Physics Protein Binding Proteins - chemistry Proteins - immunology Various methods and equipments
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Beschreibung
Zusammenfassung:	We have discovered functionalized multiwalled carbon nanotubes with reduced protein-binding, cytotoxicity, and immune response and the associated structure–activity relationships using in silico surface molecular diversity design, combinatorial library synthesis, and multiple biological screenings. Our results demonstrated the general utility of the nanocombinatorial library approach in nanomedicine and nanotoxicity research.
ISSN:	1530-6984 1530-6992
DOI:	10.1021/nl0730155