Deconstructing and reconstructing the mouse and human early embryo
The emergence of form and function during mammalian embryogenesis is a complex process that involves multiple regulatory levels. The foundations of the body plan are laid throughout the first days of post-implantation development as embryonic stem cells undergo symmetry breaking and initiate lineage...
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Veröffentlicht in: | Nature cell biology 2018-08, Vol.20 (8), p.878-887 |
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Hauptverfasser: | , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | The emergence of form and function during mammalian embryogenesis is a complex process that involves multiple regulatory levels. The foundations of the body plan are laid throughout the first days of post-implantation development as embryonic stem cells undergo symmetry breaking and initiate lineage specification, in a process that coincides with a global morphological reorganization of the embryo. Here, we review experimental models and how they have shaped our current understanding of the post-implantation mammalian embryo.
Shahbazi et al. review our current understanding of the post-implantation mammalian embryo and how innovative technologies have helped to shape it. |
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ISSN: | 1465-7392 1476-4679 |
DOI: | 10.1038/s41556-018-0144-x |