Association of alcohol-metabolizing genes with alcoholism in a Mexican Indian (Otomi) population

Association studies provide a powerful approach to link DNA variants and genetic predisposition to complex diseases. In this study, we determined the genotype and allelic frequencies of genes encoding enzymes involved in alcohol metabolism in alcoholic and nonalcoholic subjects of related ethnicity....

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Veröffentlicht in:	Alcohol (Fayetteville, N.Y.) N.Y.), 2006-06, Vol.39 (2), p.73-79
Hauptverfasser:	Montano Loza, Aldo J., Ramirez Iglesias, Maria Teresa, Perez Diaz, Ivan, Cruz Castellanos, Socorro, Garcia Andrade, Consuelo, Medina Mora, Maria Elena, Robles Díaz, Guillermo, Kershenobich, David, Gutierrez Reyes, Gabriela
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Alcohol dehydrogenase Alcohol Dehydrogenase - genetics Alcohol use Alcoholism Alcoholism - genetics Alcoholism - metabolism Aldehyde dehydrogenase Aldehyde Dehydrogenase - genetics Aldehyde Dehydrogenase, Mitochondrial CYP2E1 Cytochrome P-450 CYP2E1 - genetics Deoxyribonucleases, Type II Site-Specific - metabolism Ethanol - metabolism Female Gene Frequency Genes Genotype Humans Indians, North American - genetics Liver cirrhosis Male Mexico Middle Aged Polymorphism, Restriction Fragment Length Polymorphisms
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Zusammenfassung:	Association studies provide a powerful approach to link DNA variants and genetic predisposition to complex diseases. In this study, we determined the genotype and allelic frequencies of genes encoding enzymes involved in alcohol metabolism in alcoholic and nonalcoholic subjects of related ethnicity. A total of 118 individuals of Otomi Mexican Indian ancestry were included. Fifty-nine were chronic alcoholics according to WHO criteria and alcohol dependents according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM IV) criteria. They were compared to 59 teetotalers or alcohol consumers of
ISSN:	0741-8329 1873-6823
DOI:	10.1016/j.alcohol.2006.07.001