Vasomotor dysfunction in human subcutaneous arteries exposed ex vivo to food-grade titanium dioxide

Vasomotor dysfunction in human subcutaneous arteries exposed ex vivo to food-grade titanium dioxide

Animal studies have shown that titanium dioxide (TiO2) exposure affects arterial vasomotor function, whereas little is known about the effects in arteries from humans. This study investigated vasomotor responses after direct exposure of human subcutaneous arteries to food-grade TiO2 (E171) (14 or 14...

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Veröffentlicht in:Food and chemical toxicology 2018-10, Vol.120, p.321-327
Hauptverfasser: Jensen, Ditte Marie, Skovsted, Gry Freja, Lykkesfeldt, Jens, Dreier, Rasmus, Berg, Jais Oliver, Jeppesen, Jørgen Lykke, Sheykhzade, Majid, Loft, Steffen, Møller, Peter
Format: Artikel
Sprache:eng
Schlagworte:
E171
Endothelial dysfunction
Nanoparticles
Titanium dioxide
Vasoconstriction
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Zusammenfassung:Animal studies have shown that titanium dioxide (TiO2) exposure affects arterial vasomotor function, whereas little is known about the effects in arteries from humans. This study investigated vasomotor responses after direct exposure of human subcutaneous arteries to food-grade TiO2 (E171) (14 or 140 μg/ml) for 30 min and 18 h. Vasomotor responses to bradykinin, 5-hydroxytryptamine (5-HT), sarafotoxin 6c (S6c) and nitroglycerin were recorded in wire-myographs. Vasoconstrictor responses to 5-HT were increased in arteries exposed to E171 for 18 h (P 
ISSN:0278-6915
1873-6351
DOI:10.1016/j.fct.2018.07.015