Catalytic Functionalization of C–H Bonds of Azulene by Carbene/Nitrene Incorporation

The selective catalytic functionalization of the C–H bond of azulene upon incorporation of carbene or nitrene units with metal-based catalysts is described. Ethyl diazoacetate or ArINTs are employed as carbene or nitrene precursors, respectively. The azulene derivatives are subsequently employed as building blocks toward more complex structures with potential use as biodegradable materials.