Fate of the Two-Component Lantibiotic Lacticin 3147 in the Gastrointestinal Tract

Fate of the Two-Component Lantibiotic Lacticin 3147 in the Gastrointestinal Tract

The component peptides of lacticin 3147 were degraded by α-chymotrypsin in vitro with a resultant loss of antimicrobial activity. Activity was also lost in ileum digesta. Following oral ingestion, neither of the lacticin 3147 peptides was detected in the gastric, jejunum, or ileum digesta of pigs, a...

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Veröffentlicht in:Applied and Environmental Microbiology 2007-11, Vol.73 (21), p.7103-7109
Hauptverfasser: Gardiner, Gillian E, Rea, Mary C, O'Riordan, Brid, O'Connor, Paula, Morgan, Sheila M, Lawlor, Peadar G, Lynch, P. Brendan, Cronin, Michael, Ross, R. Paul, Hill, Colin
Format: Artikel
Sprache:eng
Schlagworte:
Bacteriocins - metabolism
Biological and medical sciences
Chymotrypsin - metabolism
Digestive system
Food Microbiology
Fundamental and applied biological sciences. Psychology
Gastrointestinal Tract - metabolism
Microbiology
Peptides
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Zusammenfassung:The component peptides of lacticin 3147 were degraded by α-chymotrypsin in vitro with a resultant loss of antimicrobial activity. Activity was also lost in ileum digesta. Following oral ingestion, neither of the lacticin 3147 peptides was detected in the gastric, jejunum, or ileum digesta of pigs, and no lacticin 3147 activity was found in the feces. These observations suggest that lacticin 3147 ingestion is unlikely to have adverse effects, since it is probably inactivated during intestinal transit.
ISSN:0099-2240
1098-5336
DOI:10.1128/AEM.01117-07