Opsin Stability and Folding: The Role of Cys185 and Abnormal Disulfide Bond Formation in the Intradiscal Domain

The structure in the extracellular, intradiscal domain of rhodopsin surrounding the Cys110–Cys187 disulfide bond has been shown to be important for correct folding of this receptor in vivo. Retinitis pigmentosa misfolding mutants of the apoprotein opsin (such as P23H) misfold, as defined by a defici...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of molecular biology 2007-12, Vol.374 (5), p.1309-1318
Hauptverfasser: McKibbin, Craig, Toye, Ashley M., Reeves, Philip J., Khorana, H. Gobind, Edwards, Patricia C., Villa, Claudio, Booth, Paula J.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!