Iodine catalyzed reduction of quinolines under mild reaction conditions

Iodine catalyzed reduction of quinolines under mild reaction conditions

A reduction of quinolines to synthetically versatile tetrahydroquinoline molecules with I and HBpin is described. In the presence of iodine (20 mol%) as a catalyst, reduction of quinolines and other N-heteroarenes proceeded readily with hydroboranes as the reducing reagents. The broad functional-gro...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2018-08, Vol.54 (62), p.8622-8625
Hauptverfasser: Yang, Chun-Hua, Chen, Xixi, Li, Huimin, Wei, Wenbo, Yang, Zhantao, Chang, Junbiao
Format: Artikel
Sprache:eng
Schlagworte:
Chemical reduction
Iodine
Organic compounds
Reagents
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A reduction of quinolines to synthetically versatile tetrahydroquinoline molecules with I and HBpin is described. In the presence of iodine (20 mol%) as a catalyst, reduction of quinolines and other N-heteroarenes proceeded readily with hydroboranes as the reducing reagents. The broad functional-group tolerance, good yields and mild reaction conditions imply high practical utility.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc04262d