Characteristics of 1555 childhood-onset lupus in three groups based on distinct time intervals to disease diagnosis: a Brazilian multicenter study

Objective The objective of this study was to compare demographic data, clinical/laboratorial features and disease activity at diagnosis in three different groups with distinct time intervals between onset of signs/symptoms and disease diagnosis. Methods A multicenter study was performed in 1555 chil...

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Veröffentlicht in:	Lupus 2018-09, Vol.27 (10), p.1712-1717
Hauptverfasser:	Novak, G V, Molinari, B C, Ferreira, J C, Sakamoto, A P, Terreri, MT, Pereira, R M R, Saad-Magalhães, C, Aikawa, N E, Campos, L M, Len, C A, Appenzeller, S, Ferriani, V P, Silva, M F, Oliveira, S K, Islabão, A G, Sztajnbok, F R, Paim, L B, Barbosa, C M, Santos, M C, Bica, B E, Sena, E G, Moraes, A J, Rolim, A M, Spelling, P F, Scheibel, I M, Cavalcanti, A S, Matos, E N, Robazzi, T C, Guimarães, L J, Santos, F P, Silva, C T, Bonfá, E, Silva, C A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Age of Onset Anti-DNA antibodies Biomarkers - blood Brazil - epidemiology Child Child, Preschool Children Delayed Diagnosis Diagnosis Disease Progression Female Humans Leukopenia Lupus Lupus Erythematosus, Systemic - blood Lupus Erythematosus, Systemic - diagnosis Lupus Erythematosus, Systemic - epidemiology Lymphopenia Male Medical diagnosis Nephritis Palate Pleurisy Predictive Value of Tests Prognosis Proteinuria Retrospective Studies Rheumatology Risk Factors Serositis Severity of Illness Index Synovitis Systemic lupus erythematosus Thrombocytopenia Time Factors Ulcers
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Zusammenfassung:	Objective The objective of this study was to compare demographic data, clinical/laboratorial features and disease activity at diagnosis in three different groups with distinct time intervals between onset of signs/symptoms and disease diagnosis. Methods A multicenter study was performed in 1555 childhood-onset systemic lupus erythematosus (American College of Rheumatology criteria) patients from 27 pediatric rheumatology services. Patients were divided into three childhood-onset systemic lupus erythematosus groups: A: short time interval to diagnosis (
ISSN:	0961-2033 1477-0962
DOI:	10.1177/0961203318787037