Immuno-MALDI-TOF-MS in the Clinic

[...]the correlation of the MALDI-TOF-MS assay with actual alcoholism was probably even higher than stated in the paper because 5 patients were found to be false negatives and 2 were found to be false positives by the MALDITOF-MS method, showing the increased accuracy of the MS-based assay compared to the "gold standard" CE assay. [...]the assay described by Darebna et al., which used a 40-spot MALDI target, was used for the rapid and multiplexed analysis of 11 samples in triplicate. Rapid and sensitive identification ofepitope-containing peptides by direct matrix-assisted laser desorption/ionization tandem mass spectrometry of peptides affinity-bound to antibody beads.