Effects of alpha- and theta-cypermethrin insecticide on transient outward potassium current in rat hippocampal CA3 neurons
The effects of two cypermethrin insecticides, alpha-cypermethrin and theta-cypermethrin on the transient outward potassium ( I A) channels in freshly dissociated hippocampal CA3 neurons of rat, were studied using whole-cell patch clamp technique. The results indicate that alpha-cypermethrin increase...
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Veröffentlicht in: | Pesticide biochemistry and physiology 2008, Vol.90 (1), p.1-7 |
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Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The effects of two cypermethrin insecticides, alpha-cypermethrin and theta-cypermethrin on the transient outward potassium (
I
A) channels in freshly dissociated hippocampal CA3 neurons of rat, were studied using whole-cell patch clamp technique. The results indicate that alpha-cypermethrin increased the amplitude of
I
A and theta-cypermethrin decreased the amplitude of
I
A, and both of them shifted steady activation curve of
I
A towards negative potential. Theta-cypermethrin contributed in the inactivation of
I
A. Alpha-cypermethrin prolonged the time constants for the recovery from inactivation kinetics of
I
A. These results imply that transient outward potassium (
I
A) channels are the target of cypermethrin, which may explain the mechanism of toxical effects of cypermethrin on mammalian animals. |
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ISSN: | 0048-3575 1095-9939 |
DOI: | 10.1016/j.pestbp.2007.07.002 |