Effects of alpha- and theta-cypermethrin insecticide on transient outward potassium current in rat hippocampal CA3 neurons

The effects of two cypermethrin insecticides, alpha-cypermethrin and theta-cypermethrin on the transient outward potassium ( I A) channels in freshly dissociated hippocampal CA3 neurons of rat, were studied using whole-cell patch clamp technique. The results indicate that alpha-cypermethrin increase...

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Veröffentlicht in:Pesticide biochemistry and physiology 2008, Vol.90 (1), p.1-7
Hauptverfasser: Tian, Yu-Tao, Liu, Zhao-Wei, Yao, Yang, Zhang, Tao, Yang, Zhuo
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Sprache:eng
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Zusammenfassung:The effects of two cypermethrin insecticides, alpha-cypermethrin and theta-cypermethrin on the transient outward potassium ( I A) channels in freshly dissociated hippocampal CA3 neurons of rat, were studied using whole-cell patch clamp technique. The results indicate that alpha-cypermethrin increased the amplitude of I A and theta-cypermethrin decreased the amplitude of I A, and both of them shifted steady activation curve of I A towards negative potential. Theta-cypermethrin contributed in the inactivation of I A. Alpha-cypermethrin prolonged the time constants for the recovery from inactivation kinetics of I A. These results imply that transient outward potassium ( I A) channels are the target of cypermethrin, which may explain the mechanism of toxical effects of cypermethrin on mammalian animals.
ISSN:0048-3575
1095-9939
DOI:10.1016/j.pestbp.2007.07.002