Increasing Clindamycin and Trimethoprim-Sulfamethoxazole Resistance in Pediatric Staphylococcus aureus Infections

The epidemiology of Staphylococcus aureus infection in children is dynamic. We conducted a retrospective observational study on pediatric clinical cultures, performed between 2005 and 2017, that grew S aureus to determine temporal trends in antibiotic resistance. Although methicillin resistance decl...

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Veröffentlicht in:	Journal of the Pediatric Infectious Diseases Society 2019-09, Vol.8 (4), p.351-353
Hauptverfasser:	Khamash, Dina F, Voskertchian, Annie, Tamma, Pranita D, Akinboyo, Ibukunoluwa C, Carroll, Karen C, Milstone, Aaron M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Child Clindamycin - pharmacology Clindamycin - therapeutic use Drug Resistance, Multiple, Bacterial - drug effects Humans Methicillin-Resistant Staphylococcus aureus Retrospective Studies Staphylococcal Infections - drug therapy Staphylococcal Infections - epidemiology Staphylococcus aureus - drug effects Staphylococcus aureus - isolation & purification Trimethoprim, Sulfamethoxazole Drug Combination - pharmacology Trimethoprim, Sulfamethoxazole Drug Combination - therapeutic use
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Zusammenfassung:	The epidemiology of Staphylococcus aureus infection in children is dynamic. We conducted a retrospective observational study on pediatric clinical cultures, performed between 2005 and 2017, that grew S aureus to determine temporal trends in antibiotic resistance. Although methicillin resistance declined, clindamycin and trimethoprim-sulfamethoxazole resistance increased significantly, especially among community-onset isolates.
ISSN:	2048-7193 2048-7207
DOI:	10.1093/jpids/piy062