Analysis of the effects of mesoporous silica particles SBA-15 and SBA-16 in Streptococcus pneumoniae transformation process

Streptococcus pneumoniae are natural competent bacteria which requires the presence of a pheromone-like molecule to do the transformation process. This study verified the influence of mesoporous silica (SBA-15 and SBA-16) on the transformation process in S. pneumoniae using a donor DNA obtained from...

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Veröffentlicht in:Folia microbiologica 2019-01, Vol.64 (1), p.127-132
Hauptverfasser: Amstalden, Maria-Cecília Krähenbühl, Oliveira, José Diogo, Strauss, Mathias, Mazali, Italo Odone, Machado, Daisy, Theisen, Thais Holtz, Lancellotti, Marcelo
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Sprache:eng
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Zusammenfassung:Streptococcus pneumoniae are natural competent bacteria which requires the presence of a pheromone-like molecule to do the transformation process. This study verified the influence of mesoporous silica (SBA-15 and SBA-16) on the transformation process in S. pneumoniae using a donor DNA obtained from a mutant strain of this microorganism (Sp360 ∆luxS ). The results showed that mesoporous silica SBA-15 and SBA-16 particles doubled the transformation ratio frequency compared with negative control (without nanoparticles) in using SBA-15 (ratio 1.81 ± 0.04) and SBA-16 (ratio 2.18 ± 0.22). We demonstrated the how mesoporous silica nanoparticles were able to increase the pneumococcus transformations, which could possibly lead to the acquisition of virulence factor genes and resistance of antibiotics.
ISSN:0015-5632
1874-9356
DOI:10.1007/s12223-018-0631-2