Analysis of the effects of mesoporous silica particles SBA-15 and SBA-16 in Streptococcus pneumoniae transformation process
Streptococcus pneumoniae are natural competent bacteria which requires the presence of a pheromone-like molecule to do the transformation process. This study verified the influence of mesoporous silica (SBA-15 and SBA-16) on the transformation process in S. pneumoniae using a donor DNA obtained from...
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Veröffentlicht in: | Folia microbiologica 2019-01, Vol.64 (1), p.127-132 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Streptococcus pneumoniae
are natural competent bacteria which requires the presence of a pheromone-like molecule to do the transformation process. This study verified the influence of mesoporous silica (SBA-15 and SBA-16) on the transformation process in
S. pneumoniae
using a donor DNA obtained from a mutant strain of this microorganism (Sp360
∆luxS
). The results showed that mesoporous silica SBA-15 and SBA-16 particles doubled the transformation ratio frequency compared with negative control (without nanoparticles) in using SBA-15 (ratio 1.81 ± 0.04) and SBA-16 (ratio 2.18 ± 0.22). We demonstrated the how mesoporous silica nanoparticles were able to increase the pneumococcus transformations, which could possibly lead to the acquisition of virulence factor genes and resistance of antibiotics. |
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ISSN: | 0015-5632 1874-9356 |
DOI: | 10.1007/s12223-018-0631-2 |