Regioselective Acetylation of 2-Aryl-2-butene-1,4-diols and Hydrolysis of Their Diacetates Using Porcine Pancreas Lipase

Regioselective Acetylation of 2-Aryl-2-butene-1,4-diols and Hydrolysis of Their Diacetates Using Porcine Pancreas Lipase

Acetylation of 2-aryl-2-butene-1,4-diols with 10 equivalents of vinyl acetate in the presence of 50 wt % of porcine pancreas lipase (PPL) Type II regioselectively proceeded to afford the corresponding 3-aryl-4-hydroxy-2-butenyl acetates in 83–93% yields. Hydrolysis of 2-aryl-2-butene-1,4-diyl diacet...

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Veröffentlicht in:Chemistry letters 2009-09, Vol.38 (9), p.892-893
Hauptverfasser: Koyata, Naka, Nagai, Takuya, Kawasaki, Masashi, Noguchi, Takuya, Kirihara, Masayuki, Imai, Nobuyuki
Format: Artikel
Sprache:eng
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Zusammenfassung:Acetylation of 2-aryl-2-butene-1,4-diols with 10 equivalents of vinyl acetate in the presence of 50 wt % of porcine pancreas lipase (PPL) Type II regioselectively proceeded to afford the corresponding 3-aryl-4-hydroxy-2-butenyl acetates in 83–93% yields. Hydrolysis of 2-aryl-2-butene-1,4-diyl diacetates in the presence of 100 wt % of PPL Type II regioselectively afforded the corresponding 2-aryl-4-hydroxy-2-butenyl acetates in 68–95% yields.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.2009.892