Morphology and tumour‐infiltrating lymphocytes in high‐stage, high‐grade serous ovarian carcinoma correlated with long‐term survival

Aims Advanced‐stage ovarian high‐grade serous carcinoma (HGSC) is a poor‐prognosis cancer; however, a small and poorly characterised subset of patients shows long‐term survival. We aimed to establish a cohort of HGSC long‐term survivors for histopathological and molecular analysis. Methods and resul...

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Veröffentlicht in:	Histopathology 2018-12, Vol.73 (6), p.1002-1012
Hauptverfasser:	Darb‐Esfahani, Silvia, Kolaschinski, Ivonne, Trillsch, Fabian, Mahner, Sven, Concin, Nicole, Vergote, Ignace, Van Nieuwenhuysen, Els, Achimas‐Cadariu, Patriciu, Glajzer, Joanna, Woopen, Hannah, Wienert, Stefan, Taube, Eliane T, Stanske, Mandy, Kulbe, Hagen, Denkert, Carsten, Sehouli, Jalid, Braicu, Elena I
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antigen presentation Carcinoma, Endometrioid - mortality Carcinoma, Endometrioid - pathology CD3 antigen CD8 antigen Cell Shape Cystadenocarcinoma, Serous - mortality Cystadenocarcinoma, Serous - pathology Female high‐grade serous histology Humans Immunohistochemistry long‐term survival Lymphocytes T Lymphocytes, Tumor-Infiltrating - pathology Major histocompatibility complex Medical prognosis Metastases Middle Aged Morphology Ovarian cancer Ovarian carcinoma Ovarian Neoplasms - mortality Ovarian Neoplasms - pathology Paraffin Prognosis Survival Rate Tumors tumour‐infiltrating lymphocytes
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Zusammenfassung:	Aims Advanced‐stage ovarian high‐grade serous carcinoma (HGSC) is a poor‐prognosis cancer; however, a small and poorly characterised subset of patients shows long‐term survival. We aimed to establish a cohort of HGSC long‐term survivors for histopathological and molecular analysis. Methods and results Paraffin blocks from 151 patients with primary FIGO III/IV HGSC and progression‐free survival (PFS) >5 years were collected within the Tumorbank Ovarian Cancer (TOC) Network; 77 HGSC with a PFS
ISSN:	0309-0167 1365-2559
DOI:	10.1111/his.13711