The gut microbiota urolithin metabotypes revisited: the human metabolism of ellagic acid is mainly determined by aging

Understanding individuals' response to dietary bioactives is crucial for personalized nutrition. We report here for the first time in a Caucasian cohort (5-90 years, n = 839) that aging is the main factor that determines the gut microbiota involved in the ellagic acid-ellagitannin metabolism (u...

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Veröffentlicht in:	Food & function 2018-08, Vol.9 (8), p.41-416
Hauptverfasser:	Cortés-Martín, A, García-Villalba, R, González-Sarrías, A, Romo-Vaquero, M, Loria-Kohen, V, Ramírez-de-Molina, A, Tomás-Barberán, F. A, Selma, M. V, Espín, J. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Aging Aging - physiology Child Child, Preschool Cohort Studies Colorectal Neoplasms - metabolism Coumarins - metabolism Coumarins - urine Diet Ellagic acid Ellagic Acid - metabolism Female Food Humans Intestinal microflora Male Metabolic Syndrome - metabolism Metabolism Microbiota Middle Aged Nutrition Prostatic Neoplasms - metabolism Young Adult
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Zusammenfassung:	Understanding individuals' response to dietary bioactives is crucial for personalized nutrition. We report here for the first time in a Caucasian cohort (5-90 years, n = 839) that aging is the main factor that determines the gut microbiota involved in the ellagic acid-ellagitannin metabolism (urolithin metabotypes), with potential consequences for human health. Human urolithin gut microbiota metabotypes are mainly determined by aging.
ISSN:	2042-6496 2042-650X
DOI:	10.1039/c8fo00956b