Daptomycin resistance in Enterococcus faecalis prosthetic valve endocarditis

Daptomycin resistance is unusual. We report a case of clinical and bacteriological failure in a patient with Enterococcus faecalis endocarditis treated with daptomycin and review available data on daptomycin resistance. A 53-year-old male was hospitalized for native mitral valve endocarditis due to...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2008-06, Vol.61 (6), p.1394-1396
Hauptverfasser:	Hidron, Alicia I., Schuetz, Audrey N., Nolte, Frederick S., Gould, Carolyn V., Osborn, Melissa K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antibiotics Case studies Daptomycin - pharmacology Daptomycin - therapeutic use Drug resistance Drug Resistance, Bacterial emerging resistance Endocarditis, Bacterial - microbiology Enterococcus faecalis Enterococcus faecalis - drug effects Enterococcus faecalis - isolation & purification Fatal Outcome Heart surgery Humans Male Microbial Sensitivity Tests Middle Aged non-susceptible Staphylococcus infections treatment failure Treatment Outcome
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Zusammenfassung:	Daptomycin resistance is unusual. We report a case of clinical and bacteriological failure in a patient with Enterococcus faecalis endocarditis treated with daptomycin and review available data on daptomycin resistance. A 53-year-old male was hospitalized for native mitral valve endocarditis due to methicillin-susceptible Staphylococcus aureus. Treatments with nafcillin and then vancomycin were discontinued due to a severe rash with both agents. Daptomycin was initiated followed by mitral valve replacement. The patient had a complicated, 2 month hospital course. [PUBLICATION ABSTRACT]
ISSN:	0305-7453 1460-2091
DOI:	10.1093/jac/dkn105