Effects of the prebiotic mannan oligosaccharide on the experimental periodontitis in rats
Aim To evaluate the effect of the prebiotic (PREB) mannan oligosaccharide (MOS) on the progression of the experimental periodontitis (EP) and intestinal morphology in rats. Materials and Methods Forty rats were randomly allocated into groups (n = 10): C (control), PREB, EP and EP‐PREB. Groups PREB a...
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| Veröffentlicht in: | Journal of clinical periodontology 2018-09, Vol.45 (9), p.1078-1089 |
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| creator | Levi, Yara L. A. S. Novais, Gabriela S. Dias, Raisa B. Andraus, Rodrigo A. C. Messora, Michel R. Neto, Hermann B. Ervolino, Edilson Santinoni, Carolina S. Maia, Luciana P. |
| description | Aim
To evaluate the effect of the prebiotic (PREB) mannan oligosaccharide (MOS) on the progression of the experimental periodontitis (EP) and intestinal morphology in rats.
Materials and Methods
Forty rats were randomly allocated into groups (n = 10): C (control), PREB, EP and EP‐PREB. Groups PREB and EP‐PREB received MOS incorporated into the feed daily. After 30 days, groups EP and EP‐PREB received a cotton ligature around their mandibular first molars, kept for 14 days. Morphometrical, histomorphometrical, microcomputed tomography, gene expression analyses and immunohistochemistry were performed. Data were statistically analysed (p |
| doi_str_mv | 10.1111/jcpe.12987 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2068924950</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2068924950</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3577-35893f719436ce8ec8ddf60b15f985501f50573a25373cbf40ac7a121a1a41563</originalsourceid><addsrcrecordid>eNp9kLFOHDEQhq0IFA6SJg-ALNEgpCXj9Xq9LqPTQRIhQZFISWX5vGPwac_e2HsC3h4fBxQp-JuZ4tOvmY-QLwzOWcnXlR3xnNWqkx_IjLUAFQj2Z4_MgAOvWiXVATnMeQXAJOf8IzmoVYloYEb-LpxDO2UaHZ3ukI4Jlz5O3tK1CcEEGgd_G7Ox9s4k3yON4ZnDhxGTX2OYzEC3a-xjmPzkM_WBJjPlT2TfmSHj55d5RH5fLH7Nv1dX15c_5t-uKsuFlBUXneJOMtXw1mKHtut718KSCac6IYA5AUJyUwsuuV26BoyVhtXMMNMw0fIjcrrrHVP8t8E86bXPFofBBIybrGtoO1U3SkBBT_5DV3GTQrlO16zYAdXxplBnO8qmmHNCp8fyqUmPmoHeCtdb4fpZeIGPXyo3yzX2b-ir4QKwHXDvB3x8p0r_nN8sdqVP1ISKcQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2100109834</pqid></control><display><type>article</type><title>Effects of the prebiotic mannan oligosaccharide on the experimental periodontitis in rats</title><source>Wiley Online Library All Journals</source><creator>Levi, Yara L. A. S. ; Novais, Gabriela S. ; Dias, Raisa B. ; Andraus, Rodrigo A. C. ; Messora, Michel R. ; Neto, Hermann B. ; Ervolino, Edilson ; Santinoni, Carolina S. ; Maia, Luciana P.</creator><creatorcontrib>Levi, Yara L. A. S. ; Novais, Gabriela S. ; Dias, Raisa B. ; Andraus, Rodrigo A. C. ; Messora, Michel R. ; Neto, Hermann B. ; Ervolino, Edilson ; Santinoni, Carolina S. ; Maia, Luciana P.</creatorcontrib><description>Aim
To evaluate the effect of the prebiotic (PREB) mannan oligosaccharide (MOS) on the progression of the experimental periodontitis (EP) and intestinal morphology in rats.
Materials and Methods
Forty rats were randomly allocated into groups (n = 10): C (control), PREB, EP and EP‐PREB. Groups PREB and EP‐PREB received MOS incorporated into the feed daily. After 30 days, groups EP and EP‐PREB received a cotton ligature around their mandibular first molars, kept for 14 days. Morphometrical, histomorphometrical, microcomputed tomography, gene expression analyses and immunohistochemistry were performed. Data were statistically analysed (p < 0.05).
Results
Group EP‐PREB showed less interproximal bone loss, area without bone in the furcation and bone porosity, and greater bone mineral density than group EP (p < 0.05). It was also observed a significant decrease in IL‐10 and IFN‐γ gene expression, besides a decrease in TNF‐α and IL‐1β and an increase in TGF‐β immunolabeling score for group EP‐PREB. Group EP‐PREB also presented villous height and crept depth values similar to group C, while group EP presented reduced values (p < 0.05).
Conclusion
It can be concluded that the oral administration of MOS promotes a protective effect against alveolar bone loss caused by EP in rats, modifying histologic and immune‐inflammatory parameters, in addition to protecting the intestine.</description><identifier>ISSN: 0303-6979</identifier><identifier>EISSN: 1600-051X</identifier><identifier>DOI: 10.1111/jcpe.12987</identifier><identifier>PMID: 29999540</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Alveolar bone ; alveolar bone loss ; animal model ; Bone loss ; Bone mineral density ; Computed tomography ; Cotton ; Data processing ; Dentistry ; Gene expression ; Gum disease ; IL-1β ; Immunohistochemistry ; Inflammation ; Interferon ; Intestine ; Mandible ; Mannan ; Molars ; Oligosaccharides ; Oral administration ; periodontal diseases ; Periodontitis ; Porosity ; Prebiotics ; Rodents ; Teeth ; Tumor necrosis factor</subject><ispartof>Journal of clinical periodontology, 2018-09, Vol.45 (9), p.1078-1089</ispartof><rights>2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2018 John Wiley & Sons A/S</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3577-35893f719436ce8ec8ddf60b15f985501f50573a25373cbf40ac7a121a1a41563</citedby><cites>FETCH-LOGICAL-c3577-35893f719436ce8ec8ddf60b15f985501f50573a25373cbf40ac7a121a1a41563</cites><orcidid>0000-0001-5697-2587 ; 0000-0001-8485-9645</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjcpe.12987$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjcpe.12987$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29999540$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Levi, Yara L. A. S.</creatorcontrib><creatorcontrib>Novais, Gabriela S.</creatorcontrib><creatorcontrib>Dias, Raisa B.</creatorcontrib><creatorcontrib>Andraus, Rodrigo A. C.</creatorcontrib><creatorcontrib>Messora, Michel R.</creatorcontrib><creatorcontrib>Neto, Hermann B.</creatorcontrib><creatorcontrib>Ervolino, Edilson</creatorcontrib><creatorcontrib>Santinoni, Carolina S.</creatorcontrib><creatorcontrib>Maia, Luciana P.</creatorcontrib><title>Effects of the prebiotic mannan oligosaccharide on the experimental periodontitis in rats</title><title>Journal of clinical periodontology</title><addtitle>J Clin Periodontol</addtitle><description>Aim
To evaluate the effect of the prebiotic (PREB) mannan oligosaccharide (MOS) on the progression of the experimental periodontitis (EP) and intestinal morphology in rats.
Materials and Methods
Forty rats were randomly allocated into groups (n = 10): C (control), PREB, EP and EP‐PREB. Groups PREB and EP‐PREB received MOS incorporated into the feed daily. After 30 days, groups EP and EP‐PREB received a cotton ligature around their mandibular first molars, kept for 14 days. Morphometrical, histomorphometrical, microcomputed tomography, gene expression analyses and immunohistochemistry were performed. Data were statistically analysed (p < 0.05).
Results
Group EP‐PREB showed less interproximal bone loss, area without bone in the furcation and bone porosity, and greater bone mineral density than group EP (p < 0.05). It was also observed a significant decrease in IL‐10 and IFN‐γ gene expression, besides a decrease in TNF‐α and IL‐1β and an increase in TGF‐β immunolabeling score for group EP‐PREB. Group EP‐PREB also presented villous height and crept depth values similar to group C, while group EP presented reduced values (p < 0.05).
Conclusion
It can be concluded that the oral administration of MOS promotes a protective effect against alveolar bone loss caused by EP in rats, modifying histologic and immune‐inflammatory parameters, in addition to protecting the intestine.</description><subject>Alveolar bone</subject><subject>alveolar bone loss</subject><subject>animal model</subject><subject>Bone loss</subject><subject>Bone mineral density</subject><subject>Computed tomography</subject><subject>Cotton</subject><subject>Data processing</subject><subject>Dentistry</subject><subject>Gene expression</subject><subject>Gum disease</subject><subject>IL-1β</subject><subject>Immunohistochemistry</subject><subject>Inflammation</subject><subject>Interferon</subject><subject>Intestine</subject><subject>Mandible</subject><subject>Mannan</subject><subject>Molars</subject><subject>Oligosaccharides</subject><subject>Oral administration</subject><subject>periodontal diseases</subject><subject>Periodontitis</subject><subject>Porosity</subject><subject>Prebiotics</subject><subject>Rodents</subject><subject>Teeth</subject><subject>Tumor necrosis factor</subject><issn>0303-6979</issn><issn>1600-051X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kLFOHDEQhq0IFA6SJg-ALNEgpCXj9Xq9LqPTQRIhQZFISWX5vGPwac_e2HsC3h4fBxQp-JuZ4tOvmY-QLwzOWcnXlR3xnNWqkx_IjLUAFQj2Z4_MgAOvWiXVATnMeQXAJOf8IzmoVYloYEb-LpxDO2UaHZ3ukI4Jlz5O3tK1CcEEGgd_G7Ox9s4k3yON4ZnDhxGTX2OYzEC3a-xjmPzkM_WBJjPlT2TfmSHj55d5RH5fLH7Nv1dX15c_5t-uKsuFlBUXneJOMtXw1mKHtut718KSCac6IYA5AUJyUwsuuV26BoyVhtXMMNMw0fIjcrrrHVP8t8E86bXPFofBBIybrGtoO1U3SkBBT_5DV3GTQrlO16zYAdXxplBnO8qmmHNCp8fyqUmPmoHeCtdb4fpZeIGPXyo3yzX2b-ir4QKwHXDvB3x8p0r_nN8sdqVP1ISKcQ</recordid><startdate>201809</startdate><enddate>201809</enddate><creator>Levi, Yara L. A. S.</creator><creator>Novais, Gabriela S.</creator><creator>Dias, Raisa B.</creator><creator>Andraus, Rodrigo A. C.</creator><creator>Messora, Michel R.</creator><creator>Neto, Hermann B.</creator><creator>Ervolino, Edilson</creator><creator>Santinoni, Carolina S.</creator><creator>Maia, Luciana P.</creator><general>Blackwell Publishing Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5697-2587</orcidid><orcidid>https://orcid.org/0000-0001-8485-9645</orcidid></search><sort><creationdate>201809</creationdate><title>Effects of the prebiotic mannan oligosaccharide on the experimental periodontitis in rats</title><author>Levi, Yara L. A. S. ; Novais, Gabriela S. ; Dias, Raisa B. ; Andraus, Rodrigo A. C. ; Messora, Michel R. ; Neto, Hermann B. ; Ervolino, Edilson ; Santinoni, Carolina S. ; Maia, Luciana P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3577-35893f719436ce8ec8ddf60b15f985501f50573a25373cbf40ac7a121a1a41563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Alveolar bone</topic><topic>alveolar bone loss</topic><topic>animal model</topic><topic>Bone loss</topic><topic>Bone mineral density</topic><topic>Computed tomography</topic><topic>Cotton</topic><topic>Data processing</topic><topic>Dentistry</topic><topic>Gene expression</topic><topic>Gum disease</topic><topic>IL-1β</topic><topic>Immunohistochemistry</topic><topic>Inflammation</topic><topic>Interferon</topic><topic>Intestine</topic><topic>Mandible</topic><topic>Mannan</topic><topic>Molars</topic><topic>Oligosaccharides</topic><topic>Oral administration</topic><topic>periodontal diseases</topic><topic>Periodontitis</topic><topic>Porosity</topic><topic>Prebiotics</topic><topic>Rodents</topic><topic>Teeth</topic><topic>Tumor necrosis factor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Levi, Yara L. A. S.</creatorcontrib><creatorcontrib>Novais, Gabriela S.</creatorcontrib><creatorcontrib>Dias, Raisa B.</creatorcontrib><creatorcontrib>Andraus, Rodrigo A. C.</creatorcontrib><creatorcontrib>Messora, Michel R.</creatorcontrib><creatorcontrib>Neto, Hermann B.</creatorcontrib><creatorcontrib>Ervolino, Edilson</creatorcontrib><creatorcontrib>Santinoni, Carolina S.</creatorcontrib><creatorcontrib>Maia, Luciana P.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical periodontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Levi, Yara L. A. S.</au><au>Novais, Gabriela S.</au><au>Dias, Raisa B.</au><au>Andraus, Rodrigo A. C.</au><au>Messora, Michel R.</au><au>Neto, Hermann B.</au><au>Ervolino, Edilson</au><au>Santinoni, Carolina S.</au><au>Maia, Luciana P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of the prebiotic mannan oligosaccharide on the experimental periodontitis in rats</atitle><jtitle>Journal of clinical periodontology</jtitle><addtitle>J Clin Periodontol</addtitle><date>2018-09</date><risdate>2018</risdate><volume>45</volume><issue>9</issue><spage>1078</spage><epage>1089</epage><pages>1078-1089</pages><issn>0303-6979</issn><eissn>1600-051X</eissn><abstract>Aim
To evaluate the effect of the prebiotic (PREB) mannan oligosaccharide (MOS) on the progression of the experimental periodontitis (EP) and intestinal morphology in rats.
Materials and Methods
Forty rats were randomly allocated into groups (n = 10): C (control), PREB, EP and EP‐PREB. Groups PREB and EP‐PREB received MOS incorporated into the feed daily. After 30 days, groups EP and EP‐PREB received a cotton ligature around their mandibular first molars, kept for 14 days. Morphometrical, histomorphometrical, microcomputed tomography, gene expression analyses and immunohistochemistry were performed. Data were statistically analysed (p < 0.05).
Results
Group EP‐PREB showed less interproximal bone loss, area without bone in the furcation and bone porosity, and greater bone mineral density than group EP (p < 0.05). It was also observed a significant decrease in IL‐10 and IFN‐γ gene expression, besides a decrease in TNF‐α and IL‐1β and an increase in TGF‐β immunolabeling score for group EP‐PREB. Group EP‐PREB also presented villous height and crept depth values similar to group C, while group EP presented reduced values (p < 0.05).
Conclusion
It can be concluded that the oral administration of MOS promotes a protective effect against alveolar bone loss caused by EP in rats, modifying histologic and immune‐inflammatory parameters, in addition to protecting the intestine.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>29999540</pmid><doi>10.1111/jcpe.12987</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-5697-2587</orcidid><orcidid>https://orcid.org/0000-0001-8485-9645</orcidid></addata></record> |
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| source | Wiley Online Library All Journals |
| subjects | Alveolar bone alveolar bone loss animal model Bone loss Bone mineral density Computed tomography Cotton Data processing Dentistry Gene expression Gum disease IL-1β Immunohistochemistry Inflammation Interferon Intestine Mandible Mannan Molars Oligosaccharides Oral administration periodontal diseases Periodontitis Porosity Prebiotics Rodents Teeth Tumor necrosis factor |
| title | Effects of the prebiotic mannan oligosaccharide on the experimental periodontitis in rats |
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