Effects of the prebiotic mannan oligosaccharide on the experimental periodontitis in rats

Aim To evaluate the effect of the prebiotic (PREB) mannan oligosaccharide (MOS) on the progression of the experimental periodontitis (EP) and intestinal morphology in rats. Materials and Methods Forty rats were randomly allocated into groups (n = 10): C (control), PREB, EP and EP‐PREB. Groups PREB a...

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Veröffentlicht in:	Journal of clinical periodontology 2018-09, Vol.45 (9), p.1078-1089
Hauptverfasser:	Levi, Yara L. A. S., Novais, Gabriela S., Dias, Raisa B., Andraus, Rodrigo A. C., Messora, Michel R., Neto, Hermann B., Ervolino, Edilson, Santinoni, Carolina S., Maia, Luciana P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveolar bone alveolar bone loss animal model Bone loss Bone mineral density Computed tomography Cotton Data processing Dentistry Gene expression Gum disease IL-1β Immunohistochemistry Inflammation Interferon Intestine Mandible Mannan Molars Oligosaccharides Oral administration periodontal diseases Periodontitis Porosity Prebiotics Rodents Teeth Tumor necrosis factor
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Zusammenfassung:	Aim To evaluate the effect of the prebiotic (PREB) mannan oligosaccharide (MOS) on the progression of the experimental periodontitis (EP) and intestinal morphology in rats. Materials and Methods Forty rats were randomly allocated into groups (n = 10): C (control), PREB, EP and EP‐PREB. Groups PREB and EP‐PREB received MOS incorporated into the feed daily. After 30 days, groups EP and EP‐PREB received a cotton ligature around their mandibular first molars, kept for 14 days. Morphometrical, histomorphometrical, microcomputed tomography, gene expression analyses and immunohistochemistry were performed. Data were statistically analysed (p
ISSN:	0303-6979 1600-051X
DOI:	10.1111/jcpe.12987