Asymmetric synthesis of allylic amines via hydroamination of allenes with benzophenone imine

Asymmetric synthesis of allylic amines via hydroamination of allenes with benzophenone imine

Rhodium-catalyzed highly regio- and enantioselective hydroamination of allenes is reported. Exclusive branched selectivities and excellent enantioselectivities were achieved applying a rhodium(i)/Josiphos catalyst. This method permits the practical synthesis of valuable α-chiral allylic amines using...

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Veröffentlicht in:Chemical science (Cambridge) 2016-01, Vol.7 (5), p.3313-3316
Hauptverfasser: Xu, Kun, Wang, Yu-Hsuan, Khakyzadeh, Vahid, Breit, Bernhard
Format: Artikel
Sprache:eng
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Zusammenfassung:Rhodium-catalyzed highly regio- and enantioselective hydroamination of allenes is reported. Exclusive branched selectivities and excellent enantioselectivities were achieved applying a rhodium(i)/Josiphos catalyst. This method permits the practical synthesis of valuable α-chiral allylic amines using benzophenone imine as ammonia carrier.
ISSN:2041-6520
2041-6539
DOI:10.1039/c5sc04984a