Prevalence of Solid Tumors in Incidentally Detected Homogeneous Renal Masses Measuring > 20 HU on Portal Venous Phase CT

The purpose of this study was to determine the prevalence of solid tumors in incidental homogeneous renal masses with attenuation greater than 20 HU on portal venous phase CT images. In this retrospective study, the records of patients with incidental indeterminate (> 20 HU) homogeneous renal masses on portal venous phase CT scans from September 11, 2007, through March 18, 2017, were identified. Adult patients were included if they had undergone follow-up ultrasound, contrast-enhanced MRI, multiphase contrast-enhanced CT, or pathologic analysis alone to confirm the solid or cystic nature of the lesion. A single ROI was placed in the center of the mass, and lesions were characterized as ≥ 50% exophytic, < 50% exophytic, or entirely surrounded by renal parenchyma. There were 322 masses in 267 patients. The mean lesion size was 16.6 (SD, 9.8) mm (range, 9-45 mm). Lesions were ≥ 50% exophytic in 92 cases, < 50% exophytic in 111 cases, and completely surrounded by renal parenchyma in 119 cases. All nonsolid lesions were characterized as benign cysts. The numbers of solid lesions per total number of lesions in each attenuation group were: 20-30 HU (0/140), 30-40 HU (0/67), 40-50 HU (1/38), 50-60 HU (3/24), 60-70 HU (5/17), 70-80 HU (5/17), and > 80 HU (8/19). All 207 lesions in the 20- to 40-HU range were benign cysts with no solid lesions (0%; 95% CI, 0.0-1.4%). Small homogeneous renal masses measuring 20-40 HU on portal venous phase CT images are highly likely to be benign cysts.