Cyclosomatostatin- and haloperidol-induced catalepsy in Wistar rats: Differential responsiveness to sleep deprivation
•Effect of sleep deprivation (SD) on catalepsy was examined in Wistar rats.•1-h SD failed to influence cyclosomatostatin (cSST)- or haloperidol-induced catalepsy.•3-h SD inhibited cSST catalepsy but stimulated haloperidol one.•These data support the validity of cSST catalepsy as a model of parkinson...
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Veröffentlicht in: | Neuroscience letters 2018-09, Vol.684, p.72-77 |
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Sprache: | eng |
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Zusammenfassung: | •Effect of sleep deprivation (SD) on catalepsy was examined in Wistar rats.•1-h SD failed to influence cyclosomatostatin (cSST)- or haloperidol-induced catalepsy.•3-h SD inhibited cSST catalepsy but stimulated haloperidol one.•These data support the validity of cSST catalepsy as a model of parkinsonian signs.
Total sleep deprivation (SD) has been found to mitigate motor dysfunctions in Parkinson’s disease. Apparently, the similar sensitivity of an animal model for parkinsonism would support the model’s validity. Recently, we described catalepsy induced in Wistar rats by somatostatin antagonist, cyclosomatostatin (cSST); this model simulates such a disease-associated abnormality as a fall in brain somatostatin levels. To evaluate the similarity between the cSST model and Parkinson’s disease, we assessed here the responsiveness of cSST-induced catalepsy to 1-h and 3-h SD. In parallel, the influence of SD on catalepsy induced by a dopamine receptor antagonist, haloperidol, was examined. It was found that the short-term SD failed to influence cataleptic responses of both types (sleep deprived rats and undisturbed ones displayed a similar duration of immobility, p > 0.05). By contrast, 3-h SD suppressed (p |
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ISSN: | 0304-3940 1872-7972 |
DOI: | 10.1016/j.neulet.2018.07.012 |