Polymethylene derivatives of nucleic bases with omega -functional groups: VI. [8-(2-oxocyclohexyl)-9-oxooctyl]pyrimidines as potential inhibitors of pyrimidine phosphorylases

Polymethylene derivatives of nucleic bases with omega -functional groups: VI. [8-(2-oxocyclohexyl)-9-oxooctyl]pyrimidines as potential inhibitors of pyrimidine phosphorylases

New polymethylene derivatives of nucleic bases with beta -diketo function in omega -position were prepared by alkylation of uracil, thymine, and cytosine. Their physicochemical properties and effect on the E. coli uridine and thimidine phosphorylases were studied.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Russian journal of bioorganic chemistry 2008-01, Vol.34 (1), p.67-73
Hauptverfasser: Komissarov, V V, Panova, NG, Kritzyn, A M
Format: Artikel
Sprache:eng
Schlagworte:
Escherichia coli
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:New polymethylene derivatives of nucleic bases with beta -diketo function in omega -position were prepared by alkylation of uracil, thymine, and cytosine. Their physicochemical properties and effect on the E. coli uridine and thimidine phosphorylases were studied.
ISSN:1068-1620
1608-330X
DOI:10.1007/s11171-008-1009-z