2-Substituted [1]benzopyrano[4,3-d]pyrimidin-5-ones

2-Substituted [1]benzopyrano[4,3-d]pyrimidin-5-ones

A new method is reported for the synthesis of 2-R-substituted [1]benzopyrano[4,3-d]pyrimidin-5-ones (R = p-phenyl, p-chlorophenyl-, p-carbamoylphenyl-, 3-pyridinyl-, 4-pyridinyl-, 2-pyrazinyl-, pyrrolidino-,morpholino-, 3,6-dimethyl-1-pyrazolyl-) by the reaction of 4-chloro-3-formylcoumarin with sal...

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Veröffentlicht in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2007-06, Vol.43 (6), p.793-798
Hauptverfasser: Strakova, I., Petrova, M., Belyakov, S., Strakovs, A.
Format: Artikel
Sprache:eng
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Zusammenfassung:A new method is reported for the synthesis of 2-R-substituted [1]benzopyrano[4,3-d]pyrimidin-5-ones (R = p-phenyl, p-chlorophenyl-, p-carbamoylphenyl-, 3-pyridinyl-, 4-pyridinyl-, 2-pyrazinyl-, pyrrolidino-,morpholino-, 3,6-dimethyl-1-pyrazolyl-) by the reaction of 4-chloro-3-formylcoumarin with salts of the corresponding amidines RC(=NH)NH sub(2)HX in DMF in the presence of piperidine or triethylamine. 3-Formyl-4-coumarin and 2-aminobenzimidazole give
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-007-0128-4