Microbiome metabolomics reveals new drivers of human liver steatosis

Microbiome metabolomics reveals new drivers of human liver steatosis

An integrative multiomics approach in nondiabetic obese women identifies phenylacetate as a microbial metabolite contributing to the accumulation of lipids in the liver and hence to nonalcoholic steatohepatitis.

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Bibliographische Detailangaben
Veröffentlicht in:Nature medicine 2018-07, Vol.24 (7), p.906-907
Hauptverfasser: Delzenne, Nathalie M., Bindels, Laure B.
Format: Artikel
Sprache:eng
Schlagworte:
631/326/2565/2134
631/443/319/320
692/699/1503/1607/2750
Amino acids
Biomedical and Life Sciences
Biomedicine
Cancer Research
Carcinoma
Dehydrogenases
Development and progression
Fatty liver
Feces
Gene expression
Genetic aspects
Health aspects
Hepatocellular carcinoma
Infectious Diseases
Lipid metabolism
Lipids
Liver
Liver diseases
Metabolic Diseases
Metabolism
Metabolites
Metabolomics
Microbiomes
Microbiota
Microbiota (Symbiotic organisms)
Microorganisms
Molecular Medicine
Motor vehicle drivers
Neurosciences
News & Views
news-and-views
Nutrition
Nutrition research
Obesity
Overweight persons
Plasma
Steatosis
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Beschreibung
Zusammenfassung:An integrative multiomics approach in nondiabetic obese women identifies phenylacetate as a microbial metabolite contributing to the accumulation of lipids in the liver and hence to nonalcoholic steatohepatitis.
ISSN:1078-8956
1546-170X
DOI:10.1038/s41591-018-0126-3