A new strategy for hydrophobic drug delivery using a hydrophilic polymer equipped with stacking units

A new strategy for hydrophobic drug delivery using a hydrophilic polymer equipped with stacking units

A highly hydrophilic polymer equipped with guanidinium groups was used to load aromatic ring-containing hydrophobic agent doxorubicin (DOX) via π-π interaction. The results have shown that the delivery system exhibited enhanced cellular uptake and antitumor efficiency compared with free drugs. This...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2018, Vol.54 (59), p.8218-8221
Hauptverfasser: Cui, Peng-Fei, Zhuang, Wan-Ru, Hu, Xi, Xing, Lei, Yu, Ru-Yi, Qiao, Jian-Bin, He, Yu-Jing, Li, Fangyuan, Ling, Daishun, Jiang, Hu-Lin
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Doxorubicin
Drug delivery systems
Polymers
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container_end_page 8221
container_issue 59
container_start_page 8218
container_title Chemical communications (Cambridge, England)
container_volume 54
creator Cui, Peng-Fei
Zhuang, Wan-Ru
Hu, Xi
Xing, Lei
Yu, Ru-Yi
Qiao, Jian-Bin
He, Yu-Jing
Li, Fangyuan
Ling, Daishun
Jiang, Hu-Lin
description A highly hydrophilic polymer equipped with guanidinium groups was used to load aromatic ring-containing hydrophobic agent doxorubicin (DOX) via π-π interaction. The results have shown that the delivery system exhibited enhanced cellular uptake and antitumor efficiency compared with free drugs. This study opens new avenues for the application of hydrophilic polymers in drug delivery.
doi_str_mv 10.1039/c8cc04363a
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source Royal Society Of Chemistry Journals; Alma/SFX Local Collection
subjects Doxorubicin
Drug delivery systems
Polymers
title A new strategy for hydrophobic drug delivery using a hydrophilic polymer equipped with stacking units
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