A new strategy for hydrophobic drug delivery using a hydrophilic polymer equipped with stacking units

A new strategy for hydrophobic drug delivery using a hydrophilic polymer equipped with stacking units

A highly hydrophilic polymer equipped with guanidinium groups was used to load aromatic ring-containing hydrophobic agent doxorubicin (DOX) via π-π interaction. The results have shown that the delivery system exhibited enhanced cellular uptake and antitumor efficiency compared with free drugs. This...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2018, Vol.54 (59), p.8218-8221
Hauptverfasser: Cui, Peng-Fei, Zhuang, Wan-Ru, Hu, Xi, Xing, Lei, Yu, Ru-Yi, Qiao, Jian-Bin, He, Yu-Jing, Li, Fangyuan, Ling, Daishun, Jiang, Hu-Lin
Format: Artikel
Sprache:eng
Schlagworte:
Doxorubicin
Drug delivery systems
Polymers
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A highly hydrophilic polymer equipped with guanidinium groups was used to load aromatic ring-containing hydrophobic agent doxorubicin (DOX) via π-π interaction. The results have shown that the delivery system exhibited enhanced cellular uptake and antitumor efficiency compared with free drugs. This study opens new avenues for the application of hydrophilic polymers in drug delivery.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc04363a