Association of Elevated Urinary miR-126, miR-155, and miR-29b with Diabetic Kidney Disease

Effective diabetic kidney disease (DKD) biomarkers remain elusive, and urinary miRNAs represent a potential source of novel noninvasive disease sentinels. We profiled 754 miRNAs in pooled urine samples from DKD patients (n = 20), detecting significantly increased miR-126, miR-155, and miR-29b compar...

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Veröffentlicht in:	The American journal of pathology 2018-09, Vol.188 (9), p.1982-1992
Hauptverfasser:	Beltrami, Cristina, Simpson, Kate, Jesky, Mark, Wonnacott, Alexa, Carrington, Christopher, Holmans, Peter, Newbury, Lucy, Jenkins, Robert, Ashdown, Thomas, Dayan, Colin, Satchell, Simon, Corish, Peter, Cockwell, Paul, Fraser, Donald, Bowen, Timothy
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biomarkers - urine Case-Control Studies Cohort Studies Computational Biology Diabetic Nephropathies - diagnosis Diabetic Nephropathies - genetics Diabetic Nephropathies - urine Female Gene Expression Profiling Humans Male MicroRNAs - genetics MicroRNAs - urine Middle Aged Prognosis ROC Curve
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Zusammenfassung:	Effective diabetic kidney disease (DKD) biomarkers remain elusive, and urinary miRNAs represent a potential source of novel noninvasive disease sentinels. We profiled 754 miRNAs in pooled urine samples from DKD patients (n = 20), detecting significantly increased miR-126, miR-155, and miR-29b compared with controls (n = 20). These results were confirmed in an independent cohort of 89 DKD patients, 62 diabetic patients without DKD, and 41 controls: miR-126 (2.8-fold increase; P < 0.0001), miR-155 (1.8-fold increase; P
ISSN:	0002-9440 1525-2191
DOI:	10.1016/j.ajpath.2018.06.006