The eLoaD platform endows centrifugal microfluidics with on-disc power and communication

In this paper we present a comprehensive description of the design, fabrication and operation of an electrified Lab-on-a-Disc (eLoaD) system. The smart platform is developed to extend conventional Lab-on-a-Disc applications with an electronic interface, providing additional flow control and sensing...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Biosensors & bioelectronics 2018-10, Vol.117, p.464-473
Hauptverfasser: Torres Delgado, Saraí M., Korvink, Jan G., Mager, Dario
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:In this paper we present a comprehensive description of the design, fabrication and operation of an electrified Lab-on-a-Disc (eLoaD) system. The smart platform is developed to extend conventional Lab-on-a-Disc applications with an electronic interface, providing additional flow control and sensing capabilities to centrifugal microfluidics platforms. Wireless power is transferred from a Qi-compliant transmitter to the eLoaD platform during rotation. An Arduino-based microcontroller, a Bluetooth communication module, and an on-board SD-card are integrated into the platform. This generalises the applicability of the eLoaD and its modules for performing a wide range of laboratory unit operations, procedures, or diagnostic assays, all controlled wirelessly during spinning. The lightweight platform is fully reusable and modular in design and construction. An interchangeable and non-disposable application disc is fitted with the necessary sensors and/or actuators for a specific assay or experiment to be performed. A particular advantage is the ability to continuously monitor and interact with LoaD experiments, overcoming the limitations of stroboscopy. We demonstrate the applicability of the platform for three sensing experiments involving optical, electrochemical, and temperature detection, and one actuation experiment involving controlled heating/cooling. The complete electronic designs and example programming codes are extensively documented in the supplementary material for easy adaptation. •The electrified Lab-on-a-Disc (eLoaD) platform provides wireless power while spinning.•The eLoaD adds control and sensing capabilities to centrifugal microfluidics analysers.•Real-time interface and interaction with a LoaD running experiments is possible.•Spin rate and time-independent sensing and actuation enabled with the eLoaD.
ISSN:0956-5663
1873-4235
DOI:10.1016/j.bios.2018.05.056