Single bolus antithymocyte globulin versus basiliximab induction in kidney transplantation with cyclosporine triple immunosuppression : Efficacy and safety

The aim of this prospective randomized study was to examine the effect of induction immunosuppression and low initial cyclosporine (CsA) on the onset of graft function and its long-term consequences. During 1999-2001, 155 patients were randomized to single 9 mg/kg dose antithymocyte globulin (ATG)-F...

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Veröffentlicht in:	Transplantation 2007-07, Vol.84 (1), p.75-82
Hauptverfasser:	KYLLÖNEN, Lauri E, EKLUND, Björn H, PESONEN, Eero J, SALMELA, Kaija T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal - therapeutic use Antilymphocyte Serum - adverse effects Antilymphocyte Serum - therapeutic use Biological and medical sciences Cyclosporine - administration & dosage Cyclosporine - adverse effects Cyclosporine - therapeutic use Delayed Graft Function - epidemiology Delayed Graft Function - prevention & control Dose-Response Relationship, Drug Drug Therapy, Combination Female Follow-Up Studies Fundamental and applied biological sciences. Psychology Fundamental immunology Graft Rejection - epidemiology Graft Survival Humans Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - adverse effects Immunosuppressive Agents - therapeutic use Incidence Kidney - drug effects Kidney - physiopathology Kidney Transplantation Male Medical sciences Middle Aged Recombinant Fusion Proteins - administration & dosage Recombinant Fusion Proteins - adverse effects Recombinant Fusion Proteins - therapeutic use Renal Dialysis Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the urinary system Time Factors Tissue, organ and graft immunology Treatment Outcome
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Beschreibung
Zusammenfassung:	The aim of this prospective randomized study was to examine the effect of induction immunosuppression and low initial cyclosporine (CsA) on the onset of graft function and its long-term consequences. During 1999-2001, 155 patients were randomized to single 9 mg/kg dose antithymocyte globulin (ATG)-Fresenius (group A) or two 20-mg doses of basiliximab (group B) with reduced dose CsA or conventional CsA triple therapy without induction (group C). Delayed function (DGF) was lower in group A than in groups B or C (5.7% vs. 24.1% and 15.9%, P
ISSN:	0041-1337 1534-6080
DOI:	10.1097/01.tp.0000268084.64888.f3