Studies on MCM-41 mesoporous silica for drug delivery: Effect of particle morphology and amine functionalization
Mesoporous MCM-41 silica functionalized by 3-aminopropyltriethoxysilane grafting was studied as a potential carrier for controlled drug release, using ibuprofen as a test drug. For comparison, non-functionalized MCM-41 was also investigated. For the purpose of testing the effect of carrier morpholog...
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Veröffentlicht in: | Chemical engineering journal (Lausanne, Switzerland : 1996) Switzerland : 1996), 2008-03, Vol.137 (1), p.30-37 |
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Hauptverfasser: | , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Mesoporous MCM-41 silica functionalized by 3-aminopropyltriethoxysilane grafting was studied as a potential carrier for controlled drug release, using ibuprofen as a test drug. For comparison, non-functionalized MCM-41 was also investigated. For the purpose of testing the effect of carrier morphology on drug delivery rate, MCM-41 was prepared in the form of both, a powder consisting of irregularly shaped (and sized) particles and monodispersed spheres (490 to 770
nm in diameter). Amine-functionalized MCM-41 micro-spheres were found to show a significantly slower drug release rate than irregularly shaped powders, which should facilitate drug delivery control over a longer time period. |
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ISSN: | 1385-8947 1873-3212 |
DOI: | 10.1016/j.cej.2007.07.078 |