Fatty Acid Profile in Milk from Goats, Capra aegagrus hircus, Exposed to Perchlorate and its Relationship with Perchlorate Residues in Human Milk

Fatty Acid Profile in Milk from Goats, Capra aegagrus hircus, Exposed to Perchlorate and its Relationship with Perchlorate Residues in Human Milk

Polyunsaturated fatty acids (PUFA) in milk are vital for normal growth and development of infant mammals. Changes in fatty acid composition were observed in milk fat from goats dosed with perchlorate (0.1 and 1 mg/kg body weight/day) for 31 days, but the effect was not persistent. Adaptation may be...

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Veröffentlicht in:Bulletin of environmental contamination and toxicology 2007-10, Vol.79 (4), p.472-477
Hauptverfasser: Cheng, Qiuqiong, Smith, Ernest E, Kirk, Andrea B, Liu, Fujun, Boylan, Lee Mallory, McCarty, Michael E, Hart, Sybil, Dong, Linxia, Cobb, George P, Jackson, W. Andrew, Anderson, Todd A
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Body Mass Index
Body weight
Breast Feeding
Capra
Dose-Response Relationship, Drug
fatty acid composition
Fatty acids
Fatty Acids, Unsaturated - analysis
Fatty Acids, Unsaturated - chemistry
Fatty Acids, Unsaturated - metabolism
Female
Goats - metabolism
Humans
Infant
Infant, Newborn
Milk
Milk, Human - chemistry
Milk, Human - drug effects
Milk, Human - metabolism
Perchlorate
Perchlorates - metabolism
Perchlorates - toxicity
Polyunsaturated fatty acids
Pregnancy
Time Factors
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Zusammenfassung:Polyunsaturated fatty acids (PUFA) in milk are vital for normal growth and development of infant mammals. Changes in fatty acid composition were observed in milk fat from goats dosed with perchlorate (0.1 and 1 mg/kg body weight/day) for 31 days, but the effect was not persistent. Adaptation may be induced in these goats to compensate for the perchlorate effect. In an analysis of fatty acid composition in human milk samples, a weak negative correlation was observed between perchlorate concentrations and total PUFA in 38 human milk samples.
ISSN:0007-4861
1432-0800
DOI:10.1007/s00128-007-9265-9