F(ab′)2 Fragments to Overcome Daratumumab Interference in Transfusion Tests

F(ab′)2 Fragments to Overcome Daratumumab Interference in Transfusion Tests

Daratumumab is an effective agent in multiple myeloma. Its binding of CD38 on red cells causes false positive results on Coombs’ blood-compatibility testing. F(ab′) 2 fragments of daratumumab block this binding and restore the accuracy of the test.

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Bibliographische Detailangaben
Veröffentlicht in:The New England journal of medicine 2018-07, Vol.379 (1), p.90-91
Hauptverfasser: Selleng, Kathleen, Gebicka, Patrycja D, Thiele, Thomas
Format: Artikel
Sprache:eng
Schlagworte:
ADP-ribosyl Cyclase 1
Antibodies, Monoclonal - pharmacology
Coombs Test
Cross Reactions - drug effects
Histocompatibility Testing
Humans
Immunoglobulin Fab Fragments - pharmacology
Membrane Glycoproteins
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Zusammenfassung:Daratumumab is an effective agent in multiple myeloma. Its binding of CD38 on red cells causes false positive results on Coombs’ blood-compatibility testing. F(ab′) 2 fragments of daratumumab block this binding and restore the accuracy of the test.
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMc1804751