Catalytic Enantioselective Total Synthesis of the Picrotoxane Alkaloids (−)-Dendrobine, (−)-Mubironine B, and (−)-Dendroxine

A concise enantioselective total synthesis of three sesquiterpenoid alkaloids(−)-dendrobine, (−)-mubironine B, and (−)-dendroxineis presented, which highlights the state-of-art catalytic methods, including enantioselective Diels–Alder cycloaddition, iron-catalyzed aerobic lactonization, copper-catalyzed cycloisomerization, and free-radical-initiated hydroazidation.