Bioconcentration Factor Hydrophobicity Cutoff:  An Artificial Phenomenon Reconstructed

The debate on whether highly hydrophobic organic chemicals (with log K ow > 5−6) bioconcentrate less than may be expected from their hydrophobicity is still not settled. The often-observed hydrophobicity “cutoff” might either be explained by artifacts occurring during bioconcentration factor (BCF...

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Veröffentlicht in:Environmental science & technology 2007-11, Vol.41 (21), p.7363-7369
Hauptverfasser: Jonker, Michiel T. O, van der Heijden, Stephan A
Format: Artikel
Sprache:eng
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Zusammenfassung:The debate on whether highly hydrophobic organic chemicals (with log K ow > 5−6) bioconcentrate less than may be expected from their hydrophobicity is still not settled. The often-observed hydrophobicity “cutoff” might either be explained by artifacts occurring during bioconcentration factor (BCF) measurements or by a true mechanism, i.e., reduced uptake of larger molecules due to decreased membrane permeation. In this paper, we advocate there is no hydrophobicity cutoff, at least not for compounds with log K ow of up to 7.5. Data are presented on the uptake of polycyclic aromatic hydrocarbons (PAHs) in the aquatic worm Lumbriculus variegatus. For this combination of chemicals/organism, BCFs were measured using several approaches, including traditional batch uptake kinetics measurements and alternative ones, involving solid-phase microextraction (SPME), polyoxymethylene solid-phase extraction (POM-SPE), field exposures, and the substitution of living worms by dead worm material or liposomes. A hydrophobicity cutoff was observed at two levels during the traditional approach only, whereas for the other approaches it was absent. The data were used to demonstrate the presence and impact of artifacts due to so-called “third phase effects” and nonequilibrium conditions that can obscure “true uptake”. The experiments suggest that previously observed cutoff effects can be ascribed to artifacts, and that current risk assessment (often incorporating a BCF cutoff) as well as BCF measurement techniques of very hydrophobic chemicals should be revised.
ISSN:0013-936X
1520-5851
DOI:10.1021/es0709977