Exercise Training Protects Against Aging-Induced Cognitive Dysfunction via Activation of the Hippocampal PGC-1α/FNDC5/BDNF Pathway
This study aimed to determine the effect of exercise training on cognitive functioning, and hippocampal PGC-1α, FNDC5, BDNF, and other cognition-related gene and protein expression in rats. Rats were divided into 4 groups based on age [3 months (young) vs. 20 months (aged)] and training status (cont...
Gespeichert in:
| Veröffentlicht in: | Neuromolecular medicine 2018-09, Vol.20 (3), p.386-400 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 400 |
|---|---|
| container_issue | 3 |
| container_start_page | 386 |
| container_title | Neuromolecular medicine |
| container_volume | 20 |
| creator | Belviranlı, Muaz Okudan, Nilsel |
| description | This study aimed to determine the effect of exercise training on cognitive functioning, and hippocampal PGC-1α, FNDC5, BDNF, and other cognition-related gene and protein expression in rats. Rats were divided into 4 groups based on age [3 months (young) vs. 20 months (aged)] and training status (control vs. exercise training). The rats that exercised voluntarily performed exercise training for 90 days, and then all the rats underwent several methods of behavioral assessment. Locomotor activity and spatial memory were lower but anxiety scores were higher in the aged control rats, than in the young control, young exercised, and aged exercised rats (
P
|
| doi_str_mv | 10.1007/s12017-018-8500-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2064250253</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2064250253</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-c39af1a1cecb52b9fd1ce4355d7fd8b6dada94f54e99e0cf8df8714cc052d8fb3</originalsourceid><addsrcrecordid>eNp1kc1uEzEUhS0EoqXwAGyQJTZsTHw948x4GSZNW6kqWZS15fFP6irxDPZMIGueiBfhmfCQQiWkbu49vvfzsaWD0FugH4HSapaAUagIhZrUnFJSPEOnwLkgAFX5fNIFJ0Dr8gS9SumeUsYA4CU6YUJUMJ_Xp-jH-XcbtU8W30blgw8bvI7dYPWQ8GKTJ2nIPY_JVTCjtgY33Sb4we8tXh6SG4MefBfw3iu8yHKv_hw7h4c7iy9933da7Xq1xeuLhsCvn7PVzbLhs0_LmxVeq-Humzq8Ri-c2ib75qGfoS-r89vmklx_vrhqFtdEFxUbchXKgQJtdctZK5zJsiw4N5UzdTs3yihROl5aISzVrjaurqDUmnJmatcWZ-jD0beP3dfRpkHufNJ2u1XBdmOSjM5LxinjRUbf_4fed2MM-XcTVXCWSZEpOFI6dilF62Qf_U7FgwQqp4TkMSGZE5JTQnJyfvfgPLY7a_7d-BtJBtgRSHkVNjY-Pv20628Vo5ze</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2063526429</pqid></control><display><type>article</type><title>Exercise Training Protects Against Aging-Induced Cognitive Dysfunction via Activation of the Hippocampal PGC-1α/FNDC5/BDNF Pathway</title><source>SpringerLink Journals - AutoHoldings</source><creator>Belviranlı, Muaz ; Okudan, Nilsel</creator><creatorcontrib>Belviranlı, Muaz ; Okudan, Nilsel</creatorcontrib><description>This study aimed to determine the effect of exercise training on cognitive functioning, and hippocampal PGC-1α, FNDC5, BDNF, and other cognition-related gene and protein expression in rats. Rats were divided into 4 groups based on age [3 months (young) vs. 20 months (aged)] and training status (control vs. exercise training). The rats that exercised voluntarily performed exercise training for 90 days, and then all the rats underwent several methods of behavioral assessment. Locomotor activity and spatial memory were lower but anxiety scores were higher in the aged control rats, than in the young control, young exercised, and aged exercised rats (
P
< 0.05). Hippocampal BDNF, FNDC5, PGC-1α, mTOR, ARC, cF-OS, ERK, SIRT, and FOXO expressions were lower, but NF-κB expressions were higher in the aged control rats than in the young control, young exercised, and aged exercised rats (
P
< 0.05). Similarly, hippocampal BDNF and FNDC5 protein expression were lower in the aged control rats than in the young control, young exercised, and aged exercised rats (
P
< 0.05). These findings show that aging-induced cognitive dysfunction is associated with a decrease in hippocampal expression of PGC-1α, FNDC5, and BDNF, and that exercise training might improve cognitive functioning via activation of these genes and proteins.</description><identifier>ISSN: 1535-1084</identifier><identifier>EISSN: 1559-1174</identifier><identifier>DOI: 10.1007/s12017-018-8500-3</identifier><identifier>PMID: 29971668</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Aging ; Anxiety ; Biomedical and Life Sciences ; Biomedicine ; Brain-derived neurotrophic factor ; Cognitive ability ; Fitness training programs ; Forkhead protein ; Hippocampus ; Internal Medicine ; Locomotor activity ; Neurology ; Neurosciences ; NF-κB protein ; Original Paper ; Protein expression ; Rodents ; Spatial memory ; TOR protein ; Transcription activation</subject><ispartof>Neuromolecular medicine, 2018-09, Vol.20 (3), p.386-400</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>NeuroMolecular Medicine is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-c39af1a1cecb52b9fd1ce4355d7fd8b6dada94f54e99e0cf8df8714cc052d8fb3</citedby><cites>FETCH-LOGICAL-c372t-c39af1a1cecb52b9fd1ce4355d7fd8b6dada94f54e99e0cf8df8714cc052d8fb3</cites><orcidid>0000-0002-2454-8818</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12017-018-8500-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12017-018-8500-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29971668$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Belviranlı, Muaz</creatorcontrib><creatorcontrib>Okudan, Nilsel</creatorcontrib><title>Exercise Training Protects Against Aging-Induced Cognitive Dysfunction via Activation of the Hippocampal PGC-1α/FNDC5/BDNF Pathway</title><title>Neuromolecular medicine</title><addtitle>Neuromol Med</addtitle><addtitle>Neuromolecular Med</addtitle><description>This study aimed to determine the effect of exercise training on cognitive functioning, and hippocampal PGC-1α, FNDC5, BDNF, and other cognition-related gene and protein expression in rats. Rats were divided into 4 groups based on age [3 months (young) vs. 20 months (aged)] and training status (control vs. exercise training). The rats that exercised voluntarily performed exercise training for 90 days, and then all the rats underwent several methods of behavioral assessment. Locomotor activity and spatial memory were lower but anxiety scores were higher in the aged control rats, than in the young control, young exercised, and aged exercised rats (
P
< 0.05). Hippocampal BDNF, FNDC5, PGC-1α, mTOR, ARC, cF-OS, ERK, SIRT, and FOXO expressions were lower, but NF-κB expressions were higher in the aged control rats than in the young control, young exercised, and aged exercised rats (
P
< 0.05). Similarly, hippocampal BDNF and FNDC5 protein expression were lower in the aged control rats than in the young control, young exercised, and aged exercised rats (
P
< 0.05). These findings show that aging-induced cognitive dysfunction is associated with a decrease in hippocampal expression of PGC-1α, FNDC5, and BDNF, and that exercise training might improve cognitive functioning via activation of these genes and proteins.</description><subject>Aging</subject><subject>Anxiety</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain-derived neurotrophic factor</subject><subject>Cognitive ability</subject><subject>Fitness training programs</subject><subject>Forkhead protein</subject><subject>Hippocampus</subject><subject>Internal Medicine</subject><subject>Locomotor activity</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>NF-κB protein</subject><subject>Original Paper</subject><subject>Protein expression</subject><subject>Rodents</subject><subject>Spatial memory</subject><subject>TOR protein</subject><subject>Transcription activation</subject><issn>1535-1084</issn><issn>1559-1174</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1kc1uEzEUhS0EoqXwAGyQJTZsTHw948x4GSZNW6kqWZS15fFP6irxDPZMIGueiBfhmfCQQiWkbu49vvfzsaWD0FugH4HSapaAUagIhZrUnFJSPEOnwLkgAFX5fNIFJ0Dr8gS9SumeUsYA4CU6YUJUMJ_Xp-jH-XcbtU8W30blgw8bvI7dYPWQ8GKTJ2nIPY_JVTCjtgY33Sb4we8tXh6SG4MefBfw3iu8yHKv_hw7h4c7iy9933da7Xq1xeuLhsCvn7PVzbLhs0_LmxVeq-Humzq8Ri-c2ib75qGfoS-r89vmklx_vrhqFtdEFxUbchXKgQJtdctZK5zJsiw4N5UzdTs3yihROl5aISzVrjaurqDUmnJmatcWZ-jD0beP3dfRpkHufNJ2u1XBdmOSjM5LxinjRUbf_4fed2MM-XcTVXCWSZEpOFI6dilF62Qf_U7FgwQqp4TkMSGZE5JTQnJyfvfgPLY7a_7d-BtJBtgRSHkVNjY-Pv20628Vo5ze</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Belviranlı, Muaz</creator><creator>Okudan, Nilsel</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2454-8818</orcidid></search><sort><creationdate>20180901</creationdate><title>Exercise Training Protects Against Aging-Induced Cognitive Dysfunction via Activation of the Hippocampal PGC-1α/FNDC5/BDNF Pathway</title><author>Belviranlı, Muaz ; Okudan, Nilsel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-c39af1a1cecb52b9fd1ce4355d7fd8b6dada94f54e99e0cf8df8714cc052d8fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aging</topic><topic>Anxiety</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain-derived neurotrophic factor</topic><topic>Cognitive ability</topic><topic>Fitness training programs</topic><topic>Forkhead protein</topic><topic>Hippocampus</topic><topic>Internal Medicine</topic><topic>Locomotor activity</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>NF-κB protein</topic><topic>Original Paper</topic><topic>Protein expression</topic><topic>Rodents</topic><topic>Spatial memory</topic><topic>TOR protein</topic><topic>Transcription activation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Belviranlı, Muaz</creatorcontrib><creatorcontrib>Okudan, Nilsel</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Neuromolecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Belviranlı, Muaz</au><au>Okudan, Nilsel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exercise Training Protects Against Aging-Induced Cognitive Dysfunction via Activation of the Hippocampal PGC-1α/FNDC5/BDNF Pathway</atitle><jtitle>Neuromolecular medicine</jtitle><stitle>Neuromol Med</stitle><addtitle>Neuromolecular Med</addtitle><date>2018-09-01</date><risdate>2018</risdate><volume>20</volume><issue>3</issue><spage>386</spage><epage>400</epage><pages>386-400</pages><issn>1535-1084</issn><eissn>1559-1174</eissn><abstract>This study aimed to determine the effect of exercise training on cognitive functioning, and hippocampal PGC-1α, FNDC5, BDNF, and other cognition-related gene and protein expression in rats. Rats were divided into 4 groups based on age [3 months (young) vs. 20 months (aged)] and training status (control vs. exercise training). The rats that exercised voluntarily performed exercise training for 90 days, and then all the rats underwent several methods of behavioral assessment. Locomotor activity and spatial memory were lower but anxiety scores were higher in the aged control rats, than in the young control, young exercised, and aged exercised rats (
P
< 0.05). Hippocampal BDNF, FNDC5, PGC-1α, mTOR, ARC, cF-OS, ERK, SIRT, and FOXO expressions were lower, but NF-κB expressions were higher in the aged control rats than in the young control, young exercised, and aged exercised rats (
P
< 0.05). Similarly, hippocampal BDNF and FNDC5 protein expression were lower in the aged control rats than in the young control, young exercised, and aged exercised rats (
P
< 0.05). These findings show that aging-induced cognitive dysfunction is associated with a decrease in hippocampal expression of PGC-1α, FNDC5, and BDNF, and that exercise training might improve cognitive functioning via activation of these genes and proteins.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>29971668</pmid><doi>10.1007/s12017-018-8500-3</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0002-2454-8818</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1535-1084 |
| ispartof | Neuromolecular medicine, 2018-09, Vol.20 (3), p.386-400 |
| issn | 1535-1084 1559-1174 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2064250253 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Aging Anxiety Biomedical and Life Sciences Biomedicine Brain-derived neurotrophic factor Cognitive ability Fitness training programs Forkhead protein Hippocampus Internal Medicine Locomotor activity Neurology Neurosciences NF-κB protein Original Paper Protein expression Rodents Spatial memory TOR protein Transcription activation |
| title | Exercise Training Protects Against Aging-Induced Cognitive Dysfunction via Activation of the Hippocampal PGC-1α/FNDC5/BDNF Pathway |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T18%3A28%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Exercise%20Training%20Protects%20Against%20Aging-Induced%20Cognitive%20Dysfunction%20via%20Activation%20of%20the%20Hippocampal%20PGC-1%CE%B1/FNDC5/BDNF%20Pathway&rft.jtitle=Neuromolecular%20medicine&rft.au=Belviranl%C4%B1,%20Muaz&rft.date=2018-09-01&rft.volume=20&rft.issue=3&rft.spage=386&rft.epage=400&rft.pages=386-400&rft.issn=1535-1084&rft.eissn=1559-1174&rft_id=info:doi/10.1007/s12017-018-8500-3&rft_dat=%3Cproquest_cross%3E2064250253%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2063526429&rft_id=info:pmid/29971668&rfr_iscdi=true |