Exercise Training Protects Against Aging-Induced Cognitive Dysfunction via Activation of the Hippocampal PGC-1α/FNDC5/BDNF Pathway

Exercise Training Protects Against Aging-Induced Cognitive Dysfunction via Activation of the Hippocampal PGC-1α/FNDC5/BDNF Pathway

This study aimed to determine the effect of exercise training on cognitive functioning, and hippocampal PGC-1α, FNDC5, BDNF, and other cognition-related gene and protein expression in rats. Rats were divided into 4 groups based on age [3 months (young) vs. 20 months (aged)] and training status (cont...

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Veröffentlicht in:Neuromolecular medicine 2018-09, Vol.20 (3), p.386-400
Hauptverfasser: Belviranlı, Muaz, Okudan, Nilsel
Format: Artikel
Sprache:eng
Schlagworte:
Aging
Anxiety
Biomedical and Life Sciences
Biomedicine
Brain-derived neurotrophic factor
Cognitive ability
Fitness training programs
Forkhead protein
Hippocampus
Internal Medicine
Locomotor activity
Neurology
Neurosciences
NF-κB protein
Original Paper
Protein expression
Rodents
Spatial memory
TOR protein
Transcription activation
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Beschreibung
Zusammenfassung:This study aimed to determine the effect of exercise training on cognitive functioning, and hippocampal PGC-1α, FNDC5, BDNF, and other cognition-related gene and protein expression in rats. Rats were divided into 4 groups based on age [3 months (young) vs. 20 months (aged)] and training status (control vs. exercise training). The rats that exercised voluntarily performed exercise training for 90 days, and then all the rats underwent several methods of behavioral assessment. Locomotor activity and spatial memory were lower but anxiety scores were higher in the aged control rats, than in the young control, young exercised, and aged exercised rats ( P  
ISSN:1535-1084
1559-1174
DOI:10.1007/s12017-018-8500-3