Is cytomegalovirus a risk factor for haemorrhagic cystitis in allogeneic haematopoietic stem cell transplantation recipients?

Is cytomegalovirus a risk factor for haemorrhagic cystitis in allogeneic haematopoietic stem cell transplantation recipients?

Haemorrhagic cystitis (HC) is usually a serious complication in allogeneic haematopoietic stem cell transplantation (allo-HSCT) recipients. In this study, our aim was to define risk factors and outcomes for patients with HC in an allo-HSCT setting. We retrospectively evaluated 249 allo-HSCTs perform...

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Veröffentlicht in:Antiviral therapy 2018-01, Vol.23 (8), p.647-653
Hauptverfasser: Atilla, Erden, Yalciner, Merih, Atilla, Pinar Ataca, Ates, Can, Bozdag, Sinem Civriz, Yuksel, Meltem Kurt, Toprak, Selami Kocak, Gunduz, Mehmet, Ozen, Mehmet, Akan, Hamdi, Demirer, Taner, Arslan, Onder, Ilhan, Osman, Beksac, Meral, Ozcan, Muhit, Gurman, Gunhan, Topcuoglu, Pervin
Format: Artikel
Sprache:eng
Schlagworte:
Cidofovir
Cystitis
Cytomegalovirus
Graft-versus-host reaction
Hematopoietic stem cells
Multivariate analysis
Ribavirin
Risk factors
Stem cell transplantation
Stem cells
Transplants & implants
Viremia
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Zusammenfassung:Haemorrhagic cystitis (HC) is usually a serious complication in allogeneic haematopoietic stem cell transplantation (allo-HSCT) recipients. In this study, our aim was to define risk factors and outcomes for patients with HC in an allo-HSCT setting. We retrospectively evaluated 249 allo-HSCTs performed between 2011 and 2016 in our centre. HC was diagnosed in 98 patients (39%) at a median of 119 days (range 5-580) and 91 (93%) of the patients had late onset disease. In univariate analysis, HC was related to cytomegalovirus (CMV) reactivation (P
ISSN:1359-6535
2040-2058
DOI:10.3851/IMP3252