Evaluation of food allergy candidate loci in the Genetics of Food Allergy study

In line with the CanPAR study,3 we have previously reported genome-wide significant association of the C11orf30/LRRC32 locus with FA.4 Analyzing the CanPAR lead single nucleotide polymorphism (SNP), rs7936434, in the GOFA study revealed association with FA (P = 1.6 × 10−7) and with peanut allergy (P = .0024; Table II), which was significant after correction for the number of markers tested. Since rs7936434 is in high linkage disequilibrium (LD) with the previously reported, best-associated SNP of the GOFA study, rs2212434 (r2 = 0.89), both variants represent the same locus. None of the 7 candidate SNPs was associated with FA in our study (Table II). Because all CanPAR cases were recruited through peanut allergy, we then tested whether the reported associations were peanut-specific. [...]current medical guidelines recommend standardized oral food challenges as the gold standard to diagnose FA,5,6 which are, however, demanding and expensive to perform. [...]all GOFA study cases and controls originated from Germany and were ethnically homogeneous, as confirmed by STRUCTURE.