1,5-Anhydro-d-glucitol in vitreous humor and cerebrospinal fluid — A helpful tool for identification of diabetes and diabetic coma post mortem

•Full validation of an APCI-LC–MS/MS method for quantitation of 1,5-AG in VH and CSF.•Low 1,5-AG concentrations in CSF and VH indicate an ante mortem existing diabetes.•1,5-AG concentrations

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Bibliographische Detailangaben
Veröffentlicht in:	Forensic science international 2018-08, Vol.289, p.397-407
Hauptverfasser:	Sydow, Konrad, Kueting, Theresa, Musshoff, Frank, Madea, Burkhard, Hess, Cornelius
Format:	Artikel
Sprache:	eng
Schlagworte:	1,5-Anhydro-d-glucitol Autopsy Bioindicators Biomarkers Cerebrospinal fluid Coma Correlation coefficient Correlation coefficients Diabetes Diabetes mellitus Diabetic coma Diagnosis Extracellular matrix Femur Forensic sciences Glucose Hyperglycemia Identification Investigations LC–MS/MS Metabolism Physical characteristics Reabsorption Regression analysis Spectrometry Standard deviation Urine Vitreous humor
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Beschreibung
Zusammenfassung:	•Full validation of an APCI-LC–MS/MS method for quantitation of 1,5-AG in VH and CSF.•Low 1,5-AG concentrations in CSF and VH indicate an ante mortem existing diabetes.•1,5-AG concentrations
ISSN:	0379-0738 1872-6283
DOI:	10.1016/j.forsciint.2018.06.021