sFlt-1/PlGF ratio for the prediction of the time of delivery

sFlt-1/PlGF ratio for the prediction of the time of delivery

Purpose The soluble fms-like tyrosine kinase-1 (sFlt-1)/placental growth factor (PlGF) ratio has been shown to be a useful parameter for the diagnosis and prediction of preeclampsia (PE). An increased sFlt-1/PlGF ratio can be closely linked to the need to deliver. The aim of the study was to examine...

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Veröffentlicht in:Archives of gynecology and obstetrics 2018-09, Vol.298 (3), p.567-577
Hauptverfasser: Graupner, Oliver, Lobmaier, Silvia M., Ortiz, Javier U., Karge, Anne, Kuschel, Bettina
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Biomarkers
Endocrinology
Female
Fetal Growth Retardation - diagnosis
Gynecology
HELLP Syndrome - diagnosis
Human Genetics
Humans
Maternal-Fetal Medicine
Medicine
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
Placenta Growth Factor - metabolism
Pre-Eclampsia - diagnosis
Preeclampsia
Pregnancy
Prognosis
Retrospective Studies
Vascular Endothelial Growth Factor Receptor-1 - metabolism
Young Adult
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Zusammenfassung:Purpose The soluble fms-like tyrosine kinase-1 (sFlt-1)/placental growth factor (PlGF) ratio has been shown to be a useful parameter for the diagnosis and prediction of preeclampsia (PE). An increased sFlt-1/PlGF ratio can be closely linked to the need to deliver. The aim of the study was to examine the mean time until delivery (MTUD) in pregnant women with a strongly increased sFlt-1/PlGF ratio. Methods From 2010 to 2018, the sFlt-1/PlGF ratio was determined in 995 singleton pregnancies with diagnosis or suspicion of PE/HELLP syndrome and/or intrauterine growth restriction (IUGR). MTUD of patients with a value above 655 in  85 but 
ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-018-4840-3