Icariin improves SHR erectile function via inhibiting eNOS uncoupling

The aim of the study was to investigate whether or not the effect of icariin on erectile function of SHR is associated with inhibition of eNOS uncoupling. Ten 12‐week‐old male WKY rats and 10 age‐matched male SHR were evenly randomised into SHR control group, SHR+ icariin treatment group, WKY contro...

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Veröffentlicht in:	Andrologia 2018-11, Vol.50 (9), p.e13084-n/a
Hauptverfasser:	Long, Hao, Jiang, Jun, Xia, Jiyi, Jiang, Rui
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dihydrofolate reductase Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use Epimedium Erectile Dysfunction - drug therapy Erectile Dysfunction - etiology Flavonoids - pharmacology Flavonoids - therapeutic use Hypertension - complications Laboratory animals Male Monomers NAD(P)H oxidase Nitric Oxide Synthase Type III - drug effects Nitric Oxide Synthase Type III - metabolism Penis - enzymology Phytotherapy Rats, Inbred SHR Rats, Inbred WKY Rodents
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Zusammenfassung:	The aim of the study was to investigate whether or not the effect of icariin on erectile function of SHR is associated with inhibition of eNOS uncoupling. Ten 12‐week‐old male WKY rats and 10 age‐matched male SHR were evenly randomised into SHR control group, SHR+ icariin treatment group, WKY control group and WKY+ icariin group. After being treated for 4 weeks, ICPmax/MAP, the expression of NT, monomer and dimer of eNOS and the level of BH4, BH2, DHFR, NADPH oxidase and GTPCH1 in the corpus cavernosum were determined. The ICPmax/MAP and the value of BH4, DHFR and GTPCH1 in the SHR icariin treatment group were significantly higher than that of the SHR group and less than that of the WYK group and icariin‐treated WKY group (p
ISSN:	0303-4569 1439-0272
DOI:	10.1111/and.13084