Kinetically Stable Bicelles with Dilution Tolerance, Size Tunability, and Thermoresponsiveness for Drug Delivery Applications
Mixtures of a phospholipid (1,2‐dipalmitoyl‐sn‐glycero‐3‐phosphatidylcholine, DPPC) and a sodium‐cholate‐derived surfactant (SC‐C5) at room temperature formed phospholipid bilayer fragments that were edge‐stabilized by SC‐C5: so‐called “bicelles”. Because the bilayer melting point of DPPC (41 °C) is...
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| Veröffentlicht in: | Chembiochem : a European journal of chemical biology 2018-09, Vol.19 (18), p.1922-1926 |
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| container_title | Chembiochem : a European journal of chemical biology |
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| creator | Uchida, Noriyuki Nishizawa Horimoto, Noriko Yamada, Kuniyo Hikima, Takaaki Ishida, Yasuhiro |
| description | Mixtures of a phospholipid (1,2‐dipalmitoyl‐sn‐glycero‐3‐phosphatidylcholine, DPPC) and a sodium‐cholate‐derived surfactant (SC‐C5) at room temperature formed phospholipid bilayer fragments that were edge‐stabilized by SC‐C5: so‐called “bicelles”. Because the bilayer melting point of DPPC (41 °C) is above room temperature and because SC‐C5 has an exceptionally low critical micelle concentration ( |
| doi_str_mv | 10.1002/cbic.201800304 |
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Frozen membrane disks: Bicelles with structures that are kinetically frozen at room temperature were developed by assembling a phospholipid with a high bilayer melting point and a surfactant with an exceptionally low critical micelle concentration. The bicelles showed kinetic stability, dilution tolerance, size tunability, and thermoresponsiveness that could be useful in transdermal drug delivery.</description><identifier>ISSN: 1439-4227</identifier><identifier>EISSN: 1439-7633</identifier><identifier>DOI: 10.1002/cbic.201800304</identifier><identifier>PMID: 29969169</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Antibiotics, Antineoplastic - administration & dosage ; Antibiotics, Antineoplastic - pharmacokinetics ; bicelles ; biomembranes ; Cell Line ; Delayed-Action Preparations - chemistry ; Dilution ; Doxorubicin - administration & dosage ; Doxorubicin - pharmacokinetics ; Drug delivery ; Drug Delivery Systems ; Drug Liberation ; Humans ; Kinetics ; Lecithin ; Lipid Bilayers - chemistry ; Melting point ; Melting points ; Micelles ; Phosphatidylcholine ; Phosphatidylcholines - chemistry ; Phospholipids ; Sodium ; Surface-Active Agents - chemistry ; surfactants ; Temperature ; Temperature effects ; Transdermal medication</subject><ispartof>Chembiochem : a European journal of chemical biology, 2018-09, Vol.19 (18), p.1922-1926</ispartof><rights>2018 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4104-89e7642dc53f676ec7db15b4167f04d70906989bf62f6e2ee0d1de0a052ed5843</citedby><cites>FETCH-LOGICAL-c4104-89e7642dc53f676ec7db15b4167f04d70906989bf62f6e2ee0d1de0a052ed5843</cites><orcidid>0000-0002-5526-6100</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcbic.201800304$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcbic.201800304$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29969169$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Uchida, Noriyuki</creatorcontrib><creatorcontrib>Nishizawa Horimoto, Noriko</creatorcontrib><creatorcontrib>Yamada, Kuniyo</creatorcontrib><creatorcontrib>Hikima, Takaaki</creatorcontrib><creatorcontrib>Ishida, Yasuhiro</creatorcontrib><title>Kinetically Stable Bicelles with Dilution Tolerance, Size Tunability, and Thermoresponsiveness for Drug Delivery Applications</title><title>Chembiochem : a European journal of chemical biology</title><addtitle>Chembiochem</addtitle><description>Mixtures of a phospholipid (1,2‐dipalmitoyl‐sn‐glycero‐3‐phosphatidylcholine, DPPC) and a sodium‐cholate‐derived surfactant (SC‐C5) at room temperature formed phospholipid bilayer fragments that were edge‐stabilized by SC‐C5: so‐called “bicelles”. Because the bilayer melting point of DPPC (41 °C) is above room temperature and because SC‐C5 has an exceptionally low critical micelle concentration (<0.5 mm), the bicelles are kinetically frozen at room temperature. Consequently, they exist even when the mixture is diluted to a concentration of 0.04 wt %. In addition, the lateral size of the bicelles can be fine‐tuned by altering the molar ratio of DPPC to SC‐C5. On heating to ≈37 °C, the bicelles transformed into micelles composed of DPPC and SC‐C5. By taking advantage of the dilution tolerance, size tunability, and thermoresponsiveness, we demonstrated in vitro drug delivery based on use of the bicelles as carriers, which suggests their potential utility in transdermal drug delivery.
Frozen membrane disks: Bicelles with structures that are kinetically frozen at room temperature were developed by assembling a phospholipid with a high bilayer melting point and a surfactant with an exceptionally low critical micelle concentration. The bicelles showed kinetic stability, dilution tolerance, size tunability, and thermoresponsiveness that could be useful in transdermal drug delivery.</description><subject>Antibiotics, Antineoplastic - administration & dosage</subject><subject>Antibiotics, Antineoplastic - pharmacokinetics</subject><subject>bicelles</subject><subject>biomembranes</subject><subject>Cell Line</subject><subject>Delayed-Action Preparations - chemistry</subject><subject>Dilution</subject><subject>Doxorubicin - administration & dosage</subject><subject>Doxorubicin - pharmacokinetics</subject><subject>Drug delivery</subject><subject>Drug Delivery Systems</subject><subject>Drug Liberation</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Lecithin</subject><subject>Lipid Bilayers - chemistry</subject><subject>Melting point</subject><subject>Melting points</subject><subject>Micelles</subject><subject>Phosphatidylcholine</subject><subject>Phosphatidylcholines - chemistry</subject><subject>Phospholipids</subject><subject>Sodium</subject><subject>Surface-Active Agents - chemistry</subject><subject>surfactants</subject><subject>Temperature</subject><subject>Temperature effects</subject><subject>Transdermal medication</subject><issn>1439-4227</issn><issn>1439-7633</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQRi0EoqVw5YgsceHQ3Y4dx4mP7S7QqpU4dDlbjjOhrrx2sJNWQeK_k9Vui8SFk0fWmzcz-gh5z2DJAPiZbZxdcmA1QAHiBTlmolCLShbFy0MtOK-OyJuc7wFAyYK9JkdcKamYVMfk97ULODhrvJ_o7WAaj_TCWfQeM310wx1dOz8OLga6iR6TCRZP6a37hXQzBtM474bplJrQ0s0dpm1MmPsYsnvAgDnTLia6TuMPukY__6WJnve9n-ftlPktedUZn_Hd4T0h37983qwuFzffvl6tzm8WVjAQi1phJQVvbVl0spJoq7ZhZSOYrDoQbQUKpKpV00neSeSI0LIWwUDJsS1rUZyQT3tvn-LPEfOgty7vjjQB45g1B1nMllpVM_rxH_Q-jinM22nOoIZaiZLN1HJP2RRzTtjpPrmtSZNmoHfB6F0w-jmYueHDQTs2W2yf8ackZkDtgUfncfqPTq8urlZ_5X8AhJ6a_w</recordid><startdate>20180917</startdate><enddate>20180917</enddate><creator>Uchida, Noriyuki</creator><creator>Nishizawa Horimoto, Noriko</creator><creator>Yamada, Kuniyo</creator><creator>Hikima, Takaaki</creator><creator>Ishida, Yasuhiro</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5526-6100</orcidid></search><sort><creationdate>20180917</creationdate><title>Kinetically Stable Bicelles with Dilution Tolerance, Size Tunability, and Thermoresponsiveness for Drug Delivery Applications</title><author>Uchida, Noriyuki ; Nishizawa Horimoto, Noriko ; Yamada, Kuniyo ; Hikima, Takaaki ; Ishida, Yasuhiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4104-89e7642dc53f676ec7db15b4167f04d70906989bf62f6e2ee0d1de0a052ed5843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Antibiotics, Antineoplastic - administration & dosage</topic><topic>Antibiotics, Antineoplastic - pharmacokinetics</topic><topic>bicelles</topic><topic>biomembranes</topic><topic>Cell Line</topic><topic>Delayed-Action Preparations - chemistry</topic><topic>Dilution</topic><topic>Doxorubicin - administration & dosage</topic><topic>Doxorubicin - pharmacokinetics</topic><topic>Drug delivery</topic><topic>Drug Delivery Systems</topic><topic>Drug Liberation</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Lecithin</topic><topic>Lipid Bilayers - chemistry</topic><topic>Melting point</topic><topic>Melting points</topic><topic>Micelles</topic><topic>Phosphatidylcholine</topic><topic>Phosphatidylcholines - chemistry</topic><topic>Phospholipids</topic><topic>Sodium</topic><topic>Surface-Active Agents - chemistry</topic><topic>surfactants</topic><topic>Temperature</topic><topic>Temperature effects</topic><topic>Transdermal medication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Uchida, Noriyuki</creatorcontrib><creatorcontrib>Nishizawa Horimoto, Noriko</creatorcontrib><creatorcontrib>Yamada, Kuniyo</creatorcontrib><creatorcontrib>Hikima, Takaaki</creatorcontrib><creatorcontrib>Ishida, Yasuhiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chembiochem : a European journal of chemical biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uchida, Noriyuki</au><au>Nishizawa Horimoto, Noriko</au><au>Yamada, Kuniyo</au><au>Hikima, Takaaki</au><au>Ishida, Yasuhiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Kinetically Stable Bicelles with Dilution Tolerance, Size Tunability, and Thermoresponsiveness for Drug Delivery Applications</atitle><jtitle>Chembiochem : a European journal of chemical biology</jtitle><addtitle>Chembiochem</addtitle><date>2018-09-17</date><risdate>2018</risdate><volume>19</volume><issue>18</issue><spage>1922</spage><epage>1926</epage><pages>1922-1926</pages><issn>1439-4227</issn><eissn>1439-7633</eissn><abstract>Mixtures of a phospholipid (1,2‐dipalmitoyl‐sn‐glycero‐3‐phosphatidylcholine, DPPC) and a sodium‐cholate‐derived surfactant (SC‐C5) at room temperature formed phospholipid bilayer fragments that were edge‐stabilized by SC‐C5: so‐called “bicelles”. Because the bilayer melting point of DPPC (41 °C) is above room temperature and because SC‐C5 has an exceptionally low critical micelle concentration (<0.5 mm), the bicelles are kinetically frozen at room temperature. Consequently, they exist even when the mixture is diluted to a concentration of 0.04 wt %. In addition, the lateral size of the bicelles can be fine‐tuned by altering the molar ratio of DPPC to SC‐C5. On heating to ≈37 °C, the bicelles transformed into micelles composed of DPPC and SC‐C5. By taking advantage of the dilution tolerance, size tunability, and thermoresponsiveness, we demonstrated in vitro drug delivery based on use of the bicelles as carriers, which suggests their potential utility in transdermal drug delivery.
Frozen membrane disks: Bicelles with structures that are kinetically frozen at room temperature were developed by assembling a phospholipid with a high bilayer melting point and a surfactant with an exceptionally low critical micelle concentration. The bicelles showed kinetic stability, dilution tolerance, size tunability, and thermoresponsiveness that could be useful in transdermal drug delivery.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29969169</pmid><doi>10.1002/cbic.201800304</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-5526-6100</orcidid></addata></record> |
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| ispartof | Chembiochem : a European journal of chemical biology, 2018-09, Vol.19 (18), p.1922-1926 |
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| subjects | Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - pharmacokinetics bicelles biomembranes Cell Line Delayed-Action Preparations - chemistry Dilution Doxorubicin - administration & dosage Doxorubicin - pharmacokinetics Drug delivery Drug Delivery Systems Drug Liberation Humans Kinetics Lecithin Lipid Bilayers - chemistry Melting point Melting points Micelles Phosphatidylcholine Phosphatidylcholines - chemistry Phospholipids Sodium Surface-Active Agents - chemistry surfactants Temperature Temperature effects Transdermal medication |
| title | Kinetically Stable Bicelles with Dilution Tolerance, Size Tunability, and Thermoresponsiveness for Drug Delivery Applications |
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