Kinetically Stable Bicelles with Dilution Tolerance, Size Tunability, and Thermoresponsiveness for Drug Delivery Applications

Mixtures of a phospholipid (1,2‐dipalmitoyl‐sn‐glycero‐3‐phosphatidylcholine, DPPC) and a sodium‐cholate‐derived surfactant (SC‐C5) at room temperature formed phospholipid bilayer fragments that were edge‐stabilized by SC‐C5: so‐called “bicelles”. Because the bilayer melting point of DPPC (41 °C) is...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2018-09, Vol.19 (18), p.1922-1926
Hauptverfasser:	Uchida, Noriyuki, Nishizawa Horimoto, Noriko, Yamada, Kuniyo, Hikima, Takaaki, Ishida, Yasuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - pharmacokinetics bicelles biomembranes Cell Line Delayed-Action Preparations - chemistry Dilution Doxorubicin - administration & dosage Doxorubicin - pharmacokinetics Drug delivery Drug Delivery Systems Drug Liberation Humans Kinetics Lecithin Lipid Bilayers - chemistry Melting point Melting points Micelles Phosphatidylcholine Phosphatidylcholines - chemistry Phospholipids Sodium Surface-Active Agents - chemistry surfactants Temperature Temperature effects Transdermal medication
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Zusammenfassung:	Mixtures of a phospholipid (1,2‐dipalmitoyl‐sn‐glycero‐3‐phosphatidylcholine, DPPC) and a sodium‐cholate‐derived surfactant (SC‐C5) at room temperature formed phospholipid bilayer fragments that were edge‐stabilized by SC‐C5: so‐called “bicelles”. Because the bilayer melting point of DPPC (41 °C) is above room temperature and because SC‐C5 has an exceptionally low critical micelle concentration (
ISSN:	1439-4227 1439-7633
DOI:	10.1002/cbic.201800304