Is Age Trumping Genetic Profiling in Clinical Practice? Relationship of Chemotherapy Recommendation and Oncotype DX Recurrence Score in Patients Aged < 50 Years versus ≥ 50 Years, and Trends Over Time

Background Oncotype DX (oDX) is used to predict recurrence and indicate response to chemotherapy in patients with early-stage breast cancer (BC). We evaluated the relationship between age (

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Bibliographische Detailangaben
Veröffentlicht in:	Annals of surgical oncology 2018-10, Vol.25 (10), p.2875-2883
Hauptverfasser:	Williams, Austin D., Reyes, Sylvia A., Arlow, Renee L., Tchou, Julia, De La Cruz, Lucy M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Age Factors Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biomarkers, Tumor - metabolism Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - pathology Breast Oncology Chemotherapy Chemotherapy, Adjuvant Demography Female Follow-Up Studies Gene Expression Profiling - methods Humans Medicine Medicine & Public Health Middle Aged Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - pathology Nomograms Oncology Practice Patterns, Physicians' - standards Prognosis Receptor, ErbB-2 - metabolism Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Surgery Surgical Oncology Trends Tumor Burden
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Beschreibung
Zusammenfassung:	Background Oncotype DX (oDX) is used to predict recurrence and indicate response to chemotherapy in patients with early-stage breast cancer (BC). We evaluated the relationship between age (
ISSN:	1068-9265 1534-4681
DOI:	10.1245/s10434-018-6600-9