Emerging role of nutrition and the non-coding landscape in type 2 diabetes mellitus: A review of literature
With the advent of recent advances in molecular techniques and whole genome sequencing, we have come to know that the non-coding landscape (including non-coding RNAs, tRNAs and even telomeres) plays a major role in the regulation of cellular processes. Furthermore, the deregulation of this landscape...
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| Veröffentlicht in: | Gene 2018-10, Vol.675, p.54-61 |
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| container_title | Gene |
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| creator | Matboli, Marwa Shafei, Ayman Ali, Mahmoud Kamal, Kamal M. Noah, Mahmoud Lewis, Paula Habashy, Abdulrahman Ehab, Mohamed Gaber, Ahmed I. Abdelzaher, Hana |
| description | With the advent of recent advances in molecular techniques and whole genome sequencing, we have come to know that the non-coding landscape (including non-coding RNAs, tRNAs and even telomeres) plays a major role in the regulation of cellular processes. Furthermore, the deregulation of this landscape has been found to contribute to and even bring about the pathogenesis of a large number of diseases. One of such diseases is diabetes mellitus (type 2 specifically) whose incidence rate and global burden is constantly increasing. Nutrition has been proven to be a key player in the development, onset and control of type 2 diabetes mellitus. Additionally, non-coding DNA based molecular markers are emerging as biomarkers of T2D, susceptibility, and perhaps dietary supplements can modulate non-coding DNA based markers expression and function in T2D management. In this review, we provide a brief overview of the developmental origins and genetics of type 2 diabetes mellitus, how each component of the non-coding landscape contributes to the development and progression of the disease and finally we discuss how dietary interventions modulate the non-coding landscape in T2D.
•The non-coding landscape plays a major role in the regulation of cellular processes•Preliminary evidence suggests that the non-coding landscape is heavily implicated in pathogenesis of T2D•Nutrition has been proven to be a key player in the development, onset and control of type 2 diabetes mellitus•Changes in the expression patterns of the non-coding landscape have been reported due to dietary interventions in T2D |
| doi_str_mv | 10.1016/j.gene.2018.06.082 |
| format | Article |
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•The non-coding landscape plays a major role in the regulation of cellular processes•Preliminary evidence suggests that the non-coding landscape is heavily implicated in pathogenesis of T2D•Nutrition has been proven to be a key player in the development, onset and control of type 2 diabetes mellitus•Changes in the expression patterns of the non-coding landscape have been reported due to dietary interventions in T2D</description><identifier>ISSN: 0378-1119</identifier><identifier>EISSN: 1879-0038</identifier><identifier>DOI: 10.1016/j.gene.2018.06.082</identifier><identifier>PMID: 29960068</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Diabetes Mellitus, Type 2 - genetics ; Epigenesis, Genetic - physiology ; Gene-Environment Interaction ; Humans ; Non-coding DNA epigenetics ; Nutrition ; Nutritional Physiological Phenomena ; Nutritional Status ; RNA, Transfer - genetics ; RNA, Untranslated - genetics ; Telomere - genetics ; Type 2 diabetes mellitus</subject><ispartof>Gene, 2018-10, Vol.675, p.54-61</ispartof><rights>2018</rights><rights>Copyright © 2018. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-1556b8b9a46598f3f779393f78457fcf511a640c3e29936b2329fefec4b534463</citedby><cites>FETCH-LOGICAL-c356t-1556b8b9a46598f3f779393f78457fcf511a640c3e29936b2329fefec4b534463</cites><orcidid>0000-0002-6852-3954</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.gene.2018.06.082$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29960068$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matboli, Marwa</creatorcontrib><creatorcontrib>Shafei, Ayman</creatorcontrib><creatorcontrib>Ali, Mahmoud</creatorcontrib><creatorcontrib>Kamal, Kamal M.</creatorcontrib><creatorcontrib>Noah, Mahmoud</creatorcontrib><creatorcontrib>Lewis, Paula</creatorcontrib><creatorcontrib>Habashy, Abdulrahman</creatorcontrib><creatorcontrib>Ehab, Mohamed</creatorcontrib><creatorcontrib>Gaber, Ahmed I.</creatorcontrib><creatorcontrib>Abdelzaher, Hana</creatorcontrib><title>Emerging role of nutrition and the non-coding landscape in type 2 diabetes mellitus: A review of literature</title><title>Gene</title><addtitle>Gene</addtitle><description>With the advent of recent advances in molecular techniques and whole genome sequencing, we have come to know that the non-coding landscape (including non-coding RNAs, tRNAs and even telomeres) plays a major role in the regulation of cellular processes. Furthermore, the deregulation of this landscape has been found to contribute to and even bring about the pathogenesis of a large number of diseases. One of such diseases is diabetes mellitus (type 2 specifically) whose incidence rate and global burden is constantly increasing. Nutrition has been proven to be a key player in the development, onset and control of type 2 diabetes mellitus. Additionally, non-coding DNA based molecular markers are emerging as biomarkers of T2D, susceptibility, and perhaps dietary supplements can modulate non-coding DNA based markers expression and function in T2D management. In this review, we provide a brief overview of the developmental origins and genetics of type 2 diabetes mellitus, how each component of the non-coding landscape contributes to the development and progression of the disease and finally we discuss how dietary interventions modulate the non-coding landscape in T2D.
•The non-coding landscape plays a major role in the regulation of cellular processes•Preliminary evidence suggests that the non-coding landscape is heavily implicated in pathogenesis of T2D•Nutrition has been proven to be a key player in the development, onset and control of type 2 diabetes mellitus•Changes in the expression patterns of the non-coding landscape have been reported due to dietary interventions in T2D</description><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Epigenesis, Genetic - physiology</subject><subject>Gene-Environment Interaction</subject><subject>Humans</subject><subject>Non-coding DNA epigenetics</subject><subject>Nutrition</subject><subject>Nutritional Physiological Phenomena</subject><subject>Nutritional Status</subject><subject>RNA, Transfer - genetics</subject><subject>RNA, Untranslated - genetics</subject><subject>Telomere - genetics</subject><subject>Type 2 diabetes mellitus</subject><issn>0378-1119</issn><issn>1879-0038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1u1DAURi0EokPhBVggL9kk-CdxbMSmqlpaqRKbdm05zvXgIbEH26Hq29fRFJZ480lX537yPQh9pKSlhIovh3YPAVpGqGyJaIlkr9COykE1hHD5Gu0IH2RDKVVn6F3OB1Jf37O36IwpJQgRcod-XS2Q9j7scYoz4OhwWEvyxceATZhw-Qk4xNDYOG3QXGfZmiNgH3B5qsnw5M0IBTJeYJ59WfNXfIET_PHwuPXVESRT1gTv0Rtn5gwfXvIcPVxf3V_eNHc_vt9eXtw1lveiNLTvxShHZTrRK-m4GwbFVQ3Z9YOzrqfUiI5YDvUMLkbGmXLgwHZjz7tO8HP0-dR7TPH3CrnoxWdbP2cCxDVrRgSTfBADryg7oTbFnBM4fUx-MelJU6I3yfqgN8l6k6yJ0FVyXfr00r-OC0z_Vv5arcC3EwD1yuoh6Ww9BAuTT2CLnqL_X_8z2K6NVg</recordid><startdate>20181030</startdate><enddate>20181030</enddate><creator>Matboli, Marwa</creator><creator>Shafei, Ayman</creator><creator>Ali, Mahmoud</creator><creator>Kamal, Kamal M.</creator><creator>Noah, Mahmoud</creator><creator>Lewis, Paula</creator><creator>Habashy, Abdulrahman</creator><creator>Ehab, Mohamed</creator><creator>Gaber, Ahmed I.</creator><creator>Abdelzaher, Hana</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6852-3954</orcidid></search><sort><creationdate>20181030</creationdate><title>Emerging role of nutrition and the non-coding landscape in type 2 diabetes mellitus: A review of literature</title><author>Matboli, Marwa ; 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| subjects | Diabetes Mellitus, Type 2 - genetics Epigenesis, Genetic - physiology Gene-Environment Interaction Humans Non-coding DNA epigenetics Nutrition Nutritional Physiological Phenomena Nutritional Status RNA, Transfer - genetics RNA, Untranslated - genetics Telomere - genetics Type 2 diabetes mellitus |
| title | Emerging role of nutrition and the non-coding landscape in type 2 diabetes mellitus: A review of literature |
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