Emerging role of nutrition and the non-coding landscape in type 2 diabetes mellitus: A review of literature

With the advent of recent advances in molecular techniques and whole genome sequencing, we have come to know that the non-coding landscape (including non-coding RNAs, tRNAs and even telomeres) plays a major role in the regulation of cellular processes. Furthermore, the deregulation of this landscape has been found to contribute to and even bring about the pathogenesis of a large number of diseases. One of such diseases is diabetes mellitus (type 2 specifically) whose incidence rate and global burden is constantly increasing. Nutrition has been proven to be a key player in the development, onset and control of type 2 diabetes mellitus. Additionally, non-coding DNA based molecular markers are emerging as biomarkers of T2D, susceptibility, and perhaps dietary supplements can modulate non-coding DNA based markers expression and function in T2D management. In this review, we provide a brief overview of the developmental origins and genetics of type 2 diabetes mellitus, how each component of the non-coding landscape contributes to the development and progression of the disease and finally we discuss how dietary interventions modulate the non-coding landscape in T2D. •The non-coding landscape plays a major role in the regulation of cellular processes•Preliminary evidence suggests that the non-coding landscape is heavily implicated in pathogenesis of T2D•Nutrition has been proven to be a key player in the development, onset and control of type 2 diabetes mellitus•Changes in the expression patterns of the non-coding landscape have been reported due to dietary interventions in T2D