Lean on Me: Cell-Cell Interactions Release TGF-β for Local Consumption Only

Lean on Me: Cell-Cell Interactions Release TGF-β for Local Consumption Only

A new study combines detailed biochemical characterization with whole-animal genetics and computational transcriptome data mining to reveal how the LRRC33 milieu molecule imposes an exquisite level of spatial control on TGF-β signaling in the CNS. A new study combines detailed biochemical characteri...

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Veröffentlicht in:Cell 2018-06, Vol.174 (1), p.18-20
Hauptverfasser: Peterson, Aidan J., O’Connor, Michael B.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cell Communication
Microglia
Signal Transduction
Transcriptome
Transforming Growth Factor beta - genetics
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Zusammenfassung:A new study combines detailed biochemical characterization with whole-animal genetics and computational transcriptome data mining to reveal how the LRRC33 milieu molecule imposes an exquisite level of spatial control on TGF-β signaling in the CNS. A new study combines detailed biochemical characterization with whole-animal genetics and computational transcriptome data mining to reveal how the LRRC33 milieu molecule imposes an exquisite level of spatial control on TGF-β signaling in the CNS.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2018.06.008