Incognito: Are Microchimeric Fetal Stem Cells that Cross Placental Barrier Real Emissaries of Peace?

Chimerism occurs naturaly throughout gestation and can also occur as a consequence of transfusion and transplantation therapy. It consists of the acquisition and long-term persistence of a genetically distinct population of allogenic cells inside another organism. Previous reports have suggested tha...

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Veröffentlicht in:	Stem cell reviews 2018-10, Vol.14 (5), p.632-641
Hauptverfasser:	Cismaru, Cosmin Andrei, Pop, Laura, Berindan-Neagoe, Ioana
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoimmune Diseases - physiopathology Autoimmunity Biomedical and Life Sciences Biomedical Engineering and Bioengineering Cancer Cell Biology Chimerism Female Fetal Stem Cells - pathology Fetal Stem Cells - physiology Fetal Stem Cells - transplantation Fetus - cytology Fetus - physiology Fetuses Gestation Graft-versus-host reaction Humans Life Sciences Placenta Placenta - cytology Placenta - physiology Population genetics Pregnancy Regenerative Medicine/Tissue Engineering Solid tumors Stem Cells Transplantation
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Beschreibung
Zusammenfassung:	Chimerism occurs naturaly throughout gestation and can also occur as a consequence of transfusion and transplantation therapy. It consists of the acquisition and long-term persistence of a genetically distinct population of allogenic cells inside another organism. Previous reports have suggested that feto-maternal microchimerism could exert a beneficial effect on the treatment of hematological and solid tumors in patients treated by PBSCT. In this review we report the mechanism of transplacental fetal stem cell trafficking during pregnancy and the effect of their long-term persistence on autoimmunity, GVHD, PBSCT, cancer and stem cell treatment.
ISSN:	1550-8943 2629-3269 1558-6804 2629-3277
DOI:	10.1007/s12015-018-9834-9